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High serum uric acid increases the risk for nonalcoholic Fatty liver disease: a prospective observational study
- Source :
- PLoS ONE, Vol 5, Iss 7, p e11578 (2010), PLoS ONE
- Publication Year :
- 2010
- Publisher :
- Public Library of Science (PLoS), 2010.
-
Abstract
- Nonalcoholic fatty liver disease (NAFLD) is a common form of chronic liver disease, and serum uric acid is observed to be significantly elevated in NAFLD patients. However, whether this elevation is causal, a bystander, or a consequence of NAFLD remains unclear. We performed a population-based prospective study among the employees of Zhenhai Refining & Chemical Company Ltd., Ningbo, China to investigate whether the elevation of serum uric acid has a casual role for NAFLD. A total of 6890 initially NAFLD-free subjects were followed up for 3 years. Overall, 11.80% (813/6890) subjects developed NAFLD over 3 years of follow-up. The cumulative incidence of NAFLD increased with progressively higher baseline serum uric acid levels (the cumulative incidence was 7.2%, 9.5%, 11.5%, 13.8%, and 17.2% in quintile 1, quintile 2, 3, 4 and 5, respectively; P value for trend
- Subjects :
- Adult
Male
medicine.medical_specialty
Population
lcsh:Medicine
Gastroenterology and Hepatology
Chronic liver disease
Gastroenterology
Gastroenterology and Hepatology/Hepatology
Diabetes and Endocrinology/Obesity
Young Adult
chemistry.chemical_compound
Risk Factors
Internal medicine
Nonalcoholic fatty liver disease
medicine
Humans
Cumulative incidence
Prospective Studies
education
lcsh:Science
Aged
Aged, 80 and over
education.field_of_study
Multidisciplinary
business.industry
Hazard ratio
Fatty liver
lcsh:R
nutritional and metabolic diseases
Middle Aged
medicine.disease
Uric Acid
Fatty Liver
Diabetes and Endocrinology
Endocrinology
chemistry
Uric acid
Female
lcsh:Q
Metabolic syndrome
business
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 5
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....90ae4a8b546cb31f15009880106ea5b4