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Caspase-9 Activation Revealed by Semaphorin 7A Cleavage Is Independent of Apoptosis in the Aged Olfactory Bulb
- Source :
- The Journal of Neuroscience. 29:11385-11392
- Publication Year :
- 2009
- Publisher :
- Society for Neuroscience, 2009.
-
Abstract
- Caspases are essential in multicellular organisms for inducing cell death during normal development and in the immune system. However, caspases can also trigger the degenerative process under certain conditions such as pathophysiological conditions and aging. Here, we identified Semaphorin 7A (Sema7A) as a novel substrate for caspase-9 that can be used to monitor caspase-9 activity in mice, and found nonapoptotic caspase-9 activation in the aged olfactory bulb (OB). Immunostaining of the OB for the caspase-9-cleaved form of Sema7A revealed abundant caspase-9-activated cells in 2-year-old (aged) but not in 2-month-old (young) mice. In fact, various regions of the aged brain, including the OB, exhibited an increased level of caspase-9 activity. However, the number of dying cells in the aged OB was, intriguingly, much lower (
- Subjects :
- Aging
Programmed cell death
Apoptosis
Semaphorins
Substrate Specificity
Mice
Immune system
Semaphorin
Antigens, CD
Animals
Caspase
Mice, Knockout
Caspase-9
biology
General Neuroscience
Articles
Olfactory Bulb
Caspase 9
Olfactory bulb
Cell biology
Enzyme Activation
Mice, Inbred C57BL
Immunology
biology.protein
Immunostaining
Subjects
Details
- ISSN :
- 15292401 and 02706474
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- The Journal of Neuroscience
- Accession number :
- edsair.doi.dedup.....9094d9c1a4ecd093947bbb36856e810f
- Full Text :
- https://doi.org/10.1523/jneurosci.4780-08.2009