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Caspase-9 Activation Revealed by Semaphorin 7A Cleavage Is Independent of Apoptosis in the Aged Olfactory Bulb

Authors :
Hiroaki Asou
Yasuo Uchiyama
Keiuke Kuida
Shun Hamada
Hiroki Yoshida
Shizue Ohsawa
Masayuki Miura
Source :
The Journal of Neuroscience. 29:11385-11392
Publication Year :
2009
Publisher :
Society for Neuroscience, 2009.

Abstract

Caspases are essential in multicellular organisms for inducing cell death during normal development and in the immune system. However, caspases can also trigger the degenerative process under certain conditions such as pathophysiological conditions and aging. Here, we identified Semaphorin 7A (Sema7A) as a novel substrate for caspase-9 that can be used to monitor caspase-9 activity in mice, and found nonapoptotic caspase-9 activation in the aged olfactory bulb (OB). Immunostaining of the OB for the caspase-9-cleaved form of Sema7A revealed abundant caspase-9-activated cells in 2-year-old (aged) but not in 2-month-old (young) mice. In fact, various regions of the aged brain, including the OB, exhibited an increased level of caspase-9 activity. However, the number of dying cells in the aged OB was, intriguingly, much lower (

Details

ISSN :
15292401 and 02706474
Volume :
29
Database :
OpenAIRE
Journal :
The Journal of Neuroscience
Accession number :
edsair.doi.dedup.....9094d9c1a4ecd093947bbb36856e810f
Full Text :
https://doi.org/10.1523/jneurosci.4780-08.2009