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Zinc transporter 3 (ZnT3) and vesicular zinc in central nervous system function
- Source :
- Neuroscience and biobehavioral reviews. 80
- Publication Year :
- 2017
-
Abstract
- Zinc transporter 3 (ZnT3) is the sole mechanism responsible for concentrating zinc ions within synaptic vesicles in a subset of the brain's glutamatergic neurons. This vesicular zinc can then be released into the synaptic cleft in an activity-dependent fashion, where it can exert many signaling functions. This review provides a comprehensive discussion of the localization and function of ZnT3 and vesicular zinc in the central nervous system. We begin by reviewing the fundamentals of zinc homeostasis and transport, and the discovery of ZnT3. We then focus on four main topics. I) The anatomy of the zincergic system, including its development and its modulation through experience-dependent plasticity. II) The role of zinc in intracellular signaling, with a focus on how zinc affects neurotransmitter receptors and synaptic plasticity. III) The behavioural characterization of the ZnT3 KO mouse, which lacks ZnT3 and, therefore, vesicular zinc. IV) The roles of ZnT3 and vesicular zinc in health and disease.
- Subjects :
- 0301 basic medicine
Central Nervous System
Synaptic cleft
Cognitive Neuroscience
Central nervous system
chemistry.chemical_element
Zinc
Synaptic vesicle
Synaptic Transmission
03 medical and health sciences
Behavioral Neuroscience
Glutamatergic
0302 clinical medicine
Neurotransmitter receptor
medicine
Animals
Humans
Cation Transport Proteins
Chemistry
3. Good health
030104 developmental biology
Neuropsychology and Physiological Psychology
medicine.anatomical_structure
Synaptic plasticity
Developmental plasticity
Synaptic Vesicles
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 18737528
- Volume :
- 80
- Database :
- OpenAIRE
- Journal :
- Neuroscience and biobehavioral reviews
- Accession number :
- edsair.doi.dedup.....909144500124a2593b1aa797efd6fa3f