Back to Search
Start Over
Advanced Parental Age at Conception and Sex Affects Mitochondrial DNA Copy Number in Human and Fruit Flies
- Source :
- J Gerontol A Biol Sci Med Sci, Mengel-From, J, Svane, A M, Pertoldi, C, Kristensen, T N, Loeschcke, V, Skytthe, A, Christensen, K, Lindahl-Jacobsen, R, Hjelmborg, J V B & Christiansen, L 2019, ' Advanced parental age at conception and sex affects mitochondrial DNA copy number in human and fruit flies ', Journals of Gerontology. Series A: Biological Sciences & Medical Sciences, vol. 74, no. 12, glz070, pp. 1853-1860 . https://doi.org/10.1093/gerona/glz070, Mengel-From, J, Svane, A M, Pertoldi, C, Kristensen, T N, Loeschcke, V, Skytthe, A, Christensen, K, Lindahl-Jacobsen, R, Hjelmborg, J & Christiansen, L 2019, ' Advanced parental age at conception and sex affects mitochondrial DNA copy number in human and fruit flies ', The journals of gerontology. Series A, Biological sciences and medical sciences, vol. 74, no. 12, pp. 1853-1860 . https://doi.org/10.1093/gerona/glz070, Mengel-From, J, Svane, A M, Pertoldi, C, Nygaard Kristensen, T, Loeschcke, V, Skytthe, A, Christensen, K, Lindahl-Jacobsen, R, Hjelmborg, J & Christiansen, L 2019, ' Advanced Parental Age at Conception and Sex Affects Mitochondrial DNA Copy Number in Human and Fruit Flies ', The journals of gerontology. Series A, Biological sciences and medical sciences, vol. 74, no. 12, pp. 1853-1860 . https://doi.org/10.1093/gerona/glz070
- Publication Year :
- 2019
- Publisher :
- Oxford University Press, 2019.
-
Abstract
- Aging is a multifactorial trait caused by early as well as late-life circumstances. A society trend that parents deliberately delay having children is of concern to health professionals, for example as advanced parental age at conception increases disease risk profiles in offspring. We here aim to study if advanced parental age at conception affects mitochondrial DNA content, a cross-species biomarker of general health, in adult human twin offspring and in a model organism. We find no deteriorated mitochondrial DNA content at advanced parental age at conception, but human mitochondrial DNA content was higher in females than males, and the difference was twofold higher at advanced maternal age at conception. Similar parental age effects and sex-specific differences in mitochondrial DNA content were found in Drosophila melanogaster. In addition, parental longevity in humans associates with both mitochondrial DNA content and parental age at conception; thus, we carefully propose that a poorer disease risk profile from advanced parental age at conception might be surpassed by superior effects of parental successful late-life reproduction that associate with parental longevity.
- Subjects :
- Male
Parents
Aging
Mitochondrial DNA
DNA Copy Number Variations
Offspring
media_common.quotation_subject
Denmark
ved/biology.organism_classification_rank.species
Longevity
Mitochondrion
Human mitochondrial genetics
DNA, Mitochondrial
Human ageing
Medicine
Gender differences
Animals
Humans
Advanced maternal age
Model organism
Human aging
media_common
Aged
ved/biology
business.industry
Middle Aged
Mitochondria
Drosophila melanogaster
The Journal of Gerontology: Biological Sciences
Trait
Adult Children
Drosophila
Female
Geriatrics and Gerontology
Reproduction
business
Demography
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- J Gerontol A Biol Sci Med Sci, Mengel-From, J, Svane, A M, Pertoldi, C, Kristensen, T N, Loeschcke, V, Skytthe, A, Christensen, K, Lindahl-Jacobsen, R, Hjelmborg, J V B & Christiansen, L 2019, ' Advanced parental age at conception and sex affects mitochondrial DNA copy number in human and fruit flies ', Journals of Gerontology. Series A: Biological Sciences & Medical Sciences, vol. 74, no. 12, glz070, pp. 1853-1860 . https://doi.org/10.1093/gerona/glz070, Mengel-From, J, Svane, A M, Pertoldi, C, Kristensen, T N, Loeschcke, V, Skytthe, A, Christensen, K, Lindahl-Jacobsen, R, Hjelmborg, J & Christiansen, L 2019, ' Advanced parental age at conception and sex affects mitochondrial DNA copy number in human and fruit flies ', The journals of gerontology. Series A, Biological sciences and medical sciences, vol. 74, no. 12, pp. 1853-1860 . https://doi.org/10.1093/gerona/glz070, Mengel-From, J, Svane, A M, Pertoldi, C, Nygaard Kristensen, T, Loeschcke, V, Skytthe, A, Christensen, K, Lindahl-Jacobsen, R, Hjelmborg, J & Christiansen, L 2019, ' Advanced Parental Age at Conception and Sex Affects Mitochondrial DNA Copy Number in Human and Fruit Flies ', The journals of gerontology. Series A, Biological sciences and medical sciences, vol. 74, no. 12, pp. 1853-1860 . https://doi.org/10.1093/gerona/glz070
- Accession number :
- edsair.doi.dedup.....908dfe065e70f3155b50bb7e5615e23a