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Model of Morphogenesis
- Source :
- Journal of Computational Biology: A Journal of Computational Molecular Cell Biology, Journal of Computational Biology: A Journal of Computational Molecular Cell Biology, 2020, ⟨10.1089/cmb.2019.0414⟩
- Publication Year :
- 2020
- Publisher :
- HAL CCSD, 2020.
-
Abstract
- We build a theoretical model of morphogenesis. This model describes cell fate in the developing organism using the notion of epigenetic code of each cell. Namely, given the epigenetic spectra of a cell and its neighboring cells, we can determine the corresponding cell event it will perform. This means that the properties of a group of cells (comprising an embryo or its part) at any time point are also known, and thus, the evolution of an embryo can be described. By this strategy, it is possible to establish the tissue, organ, or embryo shapes at any time, starting from a zygote. As an essential part of the model, the formalization of the notion of cell potency is introduced, and the related properties are discussed.
- Subjects :
- Zygote
Epigenetic code
[SDV]Life Sciences [q-bio]
Morphogenesis
Embryonic Development
morphogenesis
Biology
Cell fate determination
Epigenesis, Genetic
03 medical and health sciences
0302 clinical medicine
Genetics
Animals
Humans
Epigenetics
Molecular Biology
Cell potency
Organism
030304 developmental biology
0303 health sciences
Embryo
Cell Differentiation
modeling
Models, Theoretical
Embryo, Mammalian
Cell biology
Computational Mathematics
Computational Theory and Mathematics
030220 oncology & carcinogenesis
Modeling and Simulation
signaling
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Journal of Computational Biology: A Journal of Computational Molecular Cell Biology, Journal of Computational Biology: A Journal of Computational Molecular Cell Biology, 2020, ⟨10.1089/cmb.2019.0414⟩
- Accession number :
- edsair.doi.dedup.....908b932b63491a4d052048e0af44a7a9
- Full Text :
- https://doi.org/10.1089/cmb.2019.0414⟩