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Preparation and Characterization of Oxybenzone-Loaded Gelatin Microspheres for Enhancement of Sunscreening Efficacy
- Source :
- Drug Delivery. 13:323-330
- Publication Year :
- 2006
- Publisher :
- Informa UK Limited, 2006.
-
Abstract
- The objective of our present study was to prepare and evaluate gelatin microspheres of oxybenzone to enhance its sunscreening efficacy. The gelatin microspheres of oxybenzone were prepared by emulsion method. Process parameters were analyzed to optimize the formulation. The in vitro drug release study was performed in pH 7.4 using cellulose acetate membrane. Microspheres prepared using oxybenzone:gelatin ratio of 1:6 showed slowest drug release and those prepared with oxybenzone:gelatin ratio of 1:2 showed fastest drug release. The gelatin microspheres of oxybenzone were incorporated in aloe vera gel. Sun exposure method using sodium nitroprusside solution was used for in vitro sunscreen efficacy testing. The formulation C5 containing oxybenzone-bearing gelatin microspheres in aloe vera gel showed best sunscreen efficacy. The formulations were evaluated for skin irritation test in human volunteers, sun protection factor, and minimum erythema dose in albino rats. These studies revealed that the incorporation of sunscreening agent-loaded microspheres into aloe vera gel greatly increased the efficacy of sunscreen formulation more than four times.
- Subjects :
- Materials science
food.ingredient
Ultraviolet Rays
Drug Compounding
Pharmaceutical Science
Pharmacology
Gelatin
Aloe vera
Microsphere
Benzophenones
chemistry.chemical_compound
Drug Delivery Systems
Sun protection factor
food
Animals
Humans
Particle Size
Skin
Chromatography
Dose-Response Relationship, Drug
biology
General Medicine
Skin Irritancy Tests
biology.organism_classification
Microspheres
Rats
Treatment Outcome
Skin irritation
chemistry
Erythema
Gelatin microspheres
Emulsion
Microscopy, Electron, Scanning
Oxybenzone
Sunscreening Agents
Subjects
Details
- ISSN :
- 15210464 and 10717544
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Drug Delivery
- Accession number :
- edsair.doi.dedup.....90822974c25d28b9b0c1d59b97a4e585