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Immunoproteasome responds to injury in the retina and brain
- Source :
- Journal of Neurochemistry. 106:158-169
- Publication Year :
- 2008
- Publisher :
- Wiley, 2008.
-
Abstract
- It is well known that immunoproteasome generates peptides for MHC Class I occupancy and recognition by cytotoxic T lymphocytes (CTL). The present study focused on evidence for alternative roles for immunoproteasome. Retina and brain were analyzed for expression of immunoproteasome subunits using immunohistochemistry and western blotting under normal conditions and after injury/stress induced by CTL attack on glia (brain) or neurons (retina). Normal retina expressed substantial levels of immunoproteasome in glia, neurons, and retinal pigment epithelium. The basal level of immunoproteasome in retina was two-fold higher than in brain; CTL-induced retinal injury further up-regulated immunoproteasome expression. Immunoproteasome up-regulation was also observed in injured brain and corresponded with expression in Purkinje cells, microglia, astrocytes, and oligodendrocytes. These results suggest that the normal environment of the retina is sufficiently challenging to require on-going expression of immunoproteasome. Further, immunoproteasome up-regulation with retinal and brain injury implies a role in neuronal protection and/or repair of damage.
- Subjects :
- Proteasome Endopeptidase Complex
Central nervous system
Mice, Transgenic
Cell Communication
Biology
Biochemistry
Retina
Article
Mice
Cellular and Molecular Neuroscience
medicine
Animals
Pigment Epithelium of Eye
Neurons
Neuronal Plasticity
Retinal pigment epithelium
Microglia
Retinitis
Brain
Recovery of Function
Nerve Regeneration
Up-Regulation
Protein Subunits
CTL
medicine.anatomical_structure
Nerve Degeneration
Encephalitis
Neuroglia
sense organs
Neuron
Neuroscience
T-Lymphocytes, Cytotoxic
Astrocyte
Subjects
Details
- ISSN :
- 14714159 and 00223042
- Volume :
- 106
- Database :
- OpenAIRE
- Journal :
- Journal of Neurochemistry
- Accession number :
- edsair.doi.dedup.....9072a923267d975fb5562fc3316e105d