Back to Search
Start Over
Obesity as a predictor of treatment-related toxicity in children with acute lymphoblastic leukaemia
- Source :
- British journal of haematology, Hoboken : Wiley-Blackwell, 2021, first on line, p. [1-9], British journal of haematology, Hoboken : Wiley-Blackwell, 2022, vol. 196, no. 5, p. 1239-12479, Egnell, C, Heyman, M, Jónsson, Ó G, Raja, R A, Niinimäki, R, Albertsen, B K, Schmiegelow, K, Stabell, N, Vaitkeviciene, G, Lepik, K, Harila-Saari, A & Ranta, S 2022, ' Obesity as a predictor of treatment-related toxicity in children with acute lymphoblastic leukaemia ', British Journal of Haematology, vol. 196, no. 5, pp. 1239-1247 . https://doi.org/10.1111/bjh.17936
- Publication Year :
- 2022
- Publisher :
- John Wiley & Sons, 2022.
-
Abstract
- Obesity is associated with poor outcomes in childhood acute lymphoblastic leukaemia (ALL). We explored whether severe treatment-related toxicity and treatment delays could explain this observation. This study included 1 443 children aged 2 center dot 0-17 center dot 9 years with ALL treated with the Nordic Society of Pediatric Haematology and Oncology (NOPHO) ALL2008 non-high-risk protocol. Prospective treatment-related toxicities registered every three-month interval were used. Patients were classified according to sex- and age-adjusted international childhood cut-off values, corresponding to adult body mass index: underweight, = 30 kg/m(2). Obese children had a higher incidence rate ratio (IRR) for severe toxic events {IRR: 1 center dot 55 [95% confidence interval (CI) 1 center dot 07-2 center dot 50]}, liver and kidney failures, bleeding, abdominal complication, suspected unexpected severe adverse reactions and hyperlipidaemia compared with healthy-weight children. Obese children aged >= 10 years had increased IRRs for asparaginase-related toxicities compared with healthy-weight older children: thromboses [IRR 2 center dot 87 (95% CI 1 center dot 00-8 center dot 21)] and anaphylactic reactions [IRR 7 center dot 95 (95% CI 2 center dot 15-29 center dot 37)] as well as higher risk for truncation of asparaginase [IRR 3 center dot 54 (95% CI 1 center dot 67-7 center dot 50)]. The high prevalence of toxicity and a higher risk of truncation of asparaginase may play a role in the poor prognosis of obese children aged >= 10 years with ALL.
- Subjects :
- Male
Pediatric Obesity
Asparaginase
Pediatrics
medicine.medical_specialty
obesity
Adolescent
Antineoplastic Agents
body mass index
Overweight
Rate ratio
Body Mass Index
chemistry.chemical_compound
medicine
Humans
childhood acute lymphoblastic leukaemia
Prospective Studies
Hematologi
Child
Adverse effect
business.industry
toxicity
Hematology
Precursor Cell Lymphoblastic Leukemia-Lymphoma
medicine.disease
Obesity
Confidence interval
adverse events
chemistry
Child, Preschool
Female
Underweight
medicine.symptom
business
Body mass index
Subjects
Details
- Language :
- English
- ISSN :
- 00071048 and 13652141
- Database :
- OpenAIRE
- Journal :
- British journal of haematology, Hoboken : Wiley-Blackwell, 2021, first on line, p. [1-9], British journal of haematology, Hoboken : Wiley-Blackwell, 2022, vol. 196, no. 5, p. 1239-12479, Egnell, C, Heyman, M, Jónsson, Ó G, Raja, R A, Niinimäki, R, Albertsen, B K, Schmiegelow, K, Stabell, N, Vaitkeviciene, G, Lepik, K, Harila-Saari, A & Ranta, S 2022, ' Obesity as a predictor of treatment-related toxicity in children with acute lymphoblastic leukaemia ', British Journal of Haematology, vol. 196, no. 5, pp. 1239-1247 . https://doi.org/10.1111/bjh.17936
- Accession number :
- edsair.doi.dedup.....906c5a469032744a846967a60fb68d66