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Gender Differences in Bile Acids and Microbiota in Relationship with Gender Dissimilarity in Steatosis Induced by Diet and FXR Inactivation
- Source :
- Scientific Reports, Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017), Scientific reports, vol 7, iss 1
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- This study aims to uncover how specific bacteria and bile acids (BAs) contribute to steatosis induced by diet and farnesoid X receptor (FXR) deficiency in both genders. A control diet (CD) and Western diet (WD), which contains high fat and carbohydrate, were used to feed wild type (WT) and FXR knockout (KO) mice followed by phenotyping characterization as well as BA and microbiota profiling. Our data revealed that male WD-fed FXR KO mice had the most severe steatosis and highest hepatic and serum lipids as well as insulin resistance among the eight studied groups. Gender differences in WD-induced steatosis, insulin sensitivity, and predicted microbiota functions were all FXR-dependent. FXR deficiency enriched Desulfovibrionaceae, Deferribacteraceae, and Helicobacteraceae, which were accompanied by increased hepatic taurine-conjugated cholic acid and β-muricholic acid as well as hepatic and serum lipids. Additionally, distinct microbiota profiles were found in WD-fed WT mice harboring simple steatosis and CD-fed FXR KO mice, in which the steatosis had a potential to develop into liver cancer. Together, the presented data revealed FXR-dependent concomitant relationships between gut microbiota, BAs, and metabolic diseases in both genders. Gender differences in BAs and microbiota may account for gender dissimilarity in metabolism and metabolic diseases.
- Subjects :
- Male
0301 basic medicine
Cytoplasmic and Nuclear
Receptors, Cytoplasmic and Nuclear
Blood lipids
Gut flora
Inbred C57BL
Oral and gastrointestinal
Mice
chemistry.chemical_compound
Receptors
Homeostasis
Mice, Knockout
2. Zero hunger
Sex Characteristics
Multidisciplinary
biology
Liver Disease
Microbiota
Statistics
Phenotype
Liver
Medicine
Female
Western
medicine.medical_specialty
Knockout
Science
Chronic Liver Disease and Cirrhosis
Article
Statistics, Nonparametric
Bile Acids and Salts
03 medical and health sciences
Insulin resistance
Internal medicine
medicine
Animals
Nonparametric
Metabolic and endocrine
Nutrition
Cholic acid
Wild type
Metabolism
Glucose Tolerance Test
Lipid Metabolism
biology.organism_classification
medicine.disease
Diet
Fatty Liver
Mice, Inbred C57BL
030104 developmental biology
Endocrinology
Gene Expression Regulation
chemistry
Diet, Western
Dysbiosis
Farnesoid X receptor
Insulin Resistance
Steatosis
Digestive Diseases
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....9068fc93e0f7bb6a4b3dc63dc96de3a2