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Metabolism bySchistosoma mansoniof a new schistosomicide: 2-[(1-methylpropyl)amino]-1-octanethiosulphuric acid
- Source :
- Parasitology. 111:177-185
- Publication Year :
- 1995
- Publisher :
- Cambridge University Press (CUP), 1995.
-
Abstract
- SUMMARYIn order to investigate the mode of action of a new class of schistosomicides, theN-alkylaminoalkanethiosulphuric acids, the ‘outer35S] 2-[(1-methylpropyl)amino]-1-octanethiosulphuric acid was synthesized. Labelling studies of adultSchistosoma mansoniwere performed in infected mice and inin vitroincubations. After a single oral dose of the drug to infected mice, 5 metabolites were detected by thin-layer chromatography in organic extracts of male and female adult schistosomes.In vitrostudies showed that the same compounds were present in organic extracts obtained from adult male and female worms. One of these metabolites was identified by mass spectroscopy as being the dimeric disulphide derivative of the parent labelled thiosulphuric acid.
- Subjects :
- Male
Schistosomicides
Sulfuric Acid Esters
Sulfur Radioisotopes
Chemical synthesis
Mice
Pharmacokinetics
medicine
Animals
Tissue Distribution
Anthelmintic
Mice, Inbred BALB C
Biomphalaria
biology
Schistosoma mansoni
Metabolism
biology.organism_classification
In vitro
Infectious Diseases
Biochemistry
Isotope Labeling
Autoradiography
Electrophoresis, Polyacrylamide Gel
Female
Indicators and Reagents
Animal Science and Zoology
Parasitology
Chromatography, Thin Layer
Trematoda
medicine.drug
Subjects
Details
- ISSN :
- 14698161 and 00311820
- Volume :
- 111
- Database :
- OpenAIRE
- Journal :
- Parasitology
- Accession number :
- edsair.doi.dedup.....905e712fffb2ed08e1f559347323176c