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Intravitreal bevacizumab (Avastin®) in proliferative diabetic retinopathy
- Source :
- Acta Ophthalmologica. 86:683-687
- Publication Year :
- 2008
- Publisher :
- Wiley, 2008.
-
Abstract
- Purpose: To evaluate the efficacy and safety of intravitreal bevacizumab in proliferative diabetic retinopathy (PDR) patients. Methods: This interventional case series study included 15 eyes of 10 patients with bilateral PDR: 13 eyes with severe PDR and active new vessels (NV) and two eyes with recurrent vitreous haemorrhages. Study eyes received a single intravitreal injection of 1.25 mg (0.05 ml) bevacizumab. All eyes were followed up for 3 months, and eight of them for 9 months. Reinjection was performed in three eyes 4–6 months after the first injection. Study eyes were evaluated by fluorescein angiography at baseline, 1, 3 and 9 months. Quantitative planimetric analysis (QPA) of NV area was measured before and after treatment. All eyes received or completed panretinal photocoagulation (PRP) 1 month after the first injection. Results: As early as at 1 month, all study eyes had a regression (paired t-test, P = 0.01) of QPA-estimated NV area. The eyes with recurrent vitreous haemorrhages had clearing of bleeding. These early effects were maintained at 3 months for all eyes and tended to be stable at 9 months. The fast and measurable efficacy of bevacizumab allowed a subsequent complete and safe PRP. Conclusion: Intravitreal bevacizumab did not reveal any side-effects and was effective in the regression of NV areas and the resolution of vitreous haemorrhages. This approach is potentially useful in allowing (within a planned temporal window) a safe and efficient PRP to be performed while minimizing the risk of its complications.
- Subjects :
- Adult
Male
Vascular Endothelial Growth Factor A
medicine.medical_specialty
genetic structures
Bevacizumab
Angiogenesis Inhibitors
Retinal Neovascularization
Antibodies, Monoclonal, Humanized
Panretinal photocoagulation
Injections
Recurrence
medicine
Humans
Fluorescein Angiography
Intravitreal bevacizumab
Aged
Diabetic Retinopathy
medicine.diagnostic_test
business.industry
Antibodies, Monoclonal
General Medicine
Diabetic retinopathy
Middle Aged
medicine.disease
Fluorescein angiography
eye diseases
Vitreous Hemorrhage
Surgery
Vitreous Body
Ophthalmology
Retreatment
Vitreous hemorrhage
Female
sense organs
business
After treatment
Case series
medicine.drug
Subjects
Details
- ISSN :
- 1755375X
- Volume :
- 86
- Database :
- OpenAIRE
- Journal :
- Acta Ophthalmologica
- Accession number :
- edsair.doi.dedup.....905de78bc13ba8820bf251d61c24a1fb