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ROBUST GENE NETWORK ANALYSIS REVEALS ALTERATION OF THE STAT5a NETWORK AS A HALLMARK OF PROSTATE CANCER
ROBUST GENE NETWORK ANALYSIS REVEALS ALTERATION OF THE STAT5a NETWORK AS A HALLMARK OF PROSTATE CANCER
- Source :
- Genome Informatics 2010.
- Publication Year :
- 2010
- Publisher :
- IMPERIAL COLLEGE PRESS, 2010.
-
Abstract
- We develop a general method to identify gene networks from pair-wise correlations between genes in a microarray data set and apply it to a public prostate cancer gene expression data from 69 primary prostate tumors. We define the degree of a node as the number of genes significantly associated with the node and identify hub genes as those with the highest degree. The correlation network was pruned using transcription factor binding information in VisANT (http://visant.bu.edu/) as a biological filter. The reliability of hub genes was determined using a strict permutation test. Separate networks for normal prostate samples, and prostate cancer samples from African Americans (AA) and European Americans (EA) were generated and compared. We found that the same hubs control disease progression in AA and EA networks. Combining AA and EA samples, we generated networks for low low (
- Subjects :
- Male
Gene regulatory network
Biology
medicine.disease_cause
Bioinformatics
White People
Article
STAT5A
Prostate cancer
Prostate
STAT5 Transcription Factor
medicine
Humans
Gene Regulatory Networks
Genes, Tumor Suppressor
Oligonucleotide Array Sequence Analysis
Microarray analysis techniques
Gene Expression Profiling
Tumor Suppressor Proteins
Computational Biology
Prostatic Neoplasms
Cancer
medicine.disease
United States
Black or African American
Gene Expression Regulation, Neoplastic
Gene expression profiling
medicine.anatomical_structure
Cancer research
Carcinogenesis
Algorithms
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Genome Informatics 2010
- Accession number :
- edsair.doi.dedup.....9053342969b97eb6f17cf8ed58ea915f
- Full Text :
- https://doi.org/10.1142/9781848166585_0012