Back to Search
Start Over
Daily intake of nicotine during cigarette smoking
- Source :
- Clinical Pharmacology and Therapeutics. 35:499-504
- Publication Year :
- 1984
- Publisher :
- Springer Science and Business Media LLC, 1984.
-
Abstract
- Daily intake of nicotine in 22 subjects was estimated from metabolic clearance data obtained after intravenous infusion of nicotine and from blood and urinary nicotine concentration data obtained over 24 hr when the subjects were smoking cigarettes. Daily intake of nicotine averaged 37.6 mg (+/- 17.7, SD) but varied widely among subjects (10.5 to 78.6 mg). Men metabolized nicotine faster than did women, but daily intake of nicotine did not differ. Intake correlated strongly with cigarettes smoked per day (r = 0.59) but not with machine-determined yield. Nicotine intake per cigarette averaged 1.04 mg (+/- 0.36) but did not correlate with machine-determined yield. Correlations between several commonly used biochemical markers of tobacco smoke and nicotine intake were examined; the afternoon (4:00 P.M.) blood level of nicotine was the best marker.
- Subjects :
- Adult
Male
Blood level
Nicotine
Metabolic Clearance Rate
Daily intake
Urinary system
Physiology
Pharmacology
Tobacco smoke
Sex Factors
Cigarette smoking
Nicotine concentration
Humans
Medicine
Infusions, Parenteral
Pharmacology (medical)
Analysis of Variance
business.industry
Smoking
Middle Aged
Carboxyhemoglobin
Female
Analysis of variance
business
medicine.drug
Subjects
Details
- ISSN :
- 15326535 and 00099236
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- Clinical Pharmacology and Therapeutics
- Accession number :
- edsair.doi.dedup.....904fc4d538123c45d1de71d4003dd4ca