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AJCC 7th edition staging classification is more applicable than AJCC 8th edition staging classification for invasive IPMN
- Source :
- World Journal of Surgical Oncology, Vol 17, Iss 1, Pp 1-8 (2019), World Journal of Surgical Oncology
- Publication Year :
- 2019
- Publisher :
- BMC, 2019.
-
Abstract
- Background Both the 7th and 8th editions of the American Joint Committee on Cancer (AJCC) staging systems have been introduced for pancreatic adenocarcinoma. However, the applicability of these classifications for invasive intraductal papillary mucinous neoplasms (IPMN) has not been systematically examined. Methods Patients with invasive IPMN were retrieved from a cohort of 18 geographical sites (1973–2014 varying) in the Surveillance, Epidemiology, and End Results (SEER) cancer registry. The 7th and 8th editions of the AJCC staging were compared. Survival rates and multivariate analyses were computed. Results In total, 1216 patients with resected invasive IPMN were included. A major difference between the 7th and 8th systems is the definition of stage IIA (7th, beyond the pancreas without involvement of major arteries; 8th, maximum tumor diameter > 4 cm). The hazard ratio (HR) of stage IIA disease (versus stage IA, HR = 2.33, P 2 cm (size > 4 cm versus > 2 ≤ 4 cm, HR = 0.91, P = 0.420). Conclusions The AJCC 7th edition staging classification is more applicable than the 8th edition classification for invasive IPMN.
- Subjects :
- End results
Adult
Male
Stage
medicine.medical_specialty
Adolescent
Pancreatic Intraductal Neoplasms
lcsh:Surgery
lcsh:RC254-282
TNM
Cohort Studies
03 medical and health sciences
Young Adult
0302 clinical medicine
Medicine
Humans
Neoplasm Invasiveness
Stage (cooking)
Aged
Neoplasm Staging
Aged, 80 and over
American Joint Committee on Cancer
Intraductal papillary mucinous neoplasm
Tumor size
business.industry
Research
Hazard ratio
Cancer
lcsh:RD1-811
Middle Aged
medicine.disease
Prognosis
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Adenocarcinoma, Mucinous
Carcinoma, Papillary
Cancer registry
Survival Rate
Oncology
030220 oncology & carcinogenesis
Adenocarcinoma
030211 gastroenterology & hepatology
Surgery
Female
Radiology
business
Carcinoma, Pancreatic Ductal
Follow-Up Studies
SEER Program
Subjects
Details
- Language :
- English
- ISSN :
- 14777819
- Volume :
- 17
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- World Journal of Surgical Oncology
- Accession number :
- edsair.doi.dedup.....904d6985fd3e2fcf23fbf7f0a196c2f2