Back to Search
Start Over
Correlation of the SUVmax of FDG-PET and ADC values of diffusion-weighted MR imaging with pathologic prognostic factors in breast carcinoma
- Source :
- European Journal of Radiology. 85:943-949
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- To correlate both primary lesion maximum standardized uptake values (SUVmax) of FDG-PET/CT, and apparent diffusion coefficient (ADC) values of diffusion-weighted imaging (DWI) with clinicopathologic prognostic factors in patients with breast carcinoma.214 patients with 216 mass-type invasive breast carcinomas underwent whole-body FDG-PET/CT and 3-Tesla breast MRI including DWI before initial therapy. The primary tumor's SUVmax and ADC values were measured using FDG-PET/CT and DWI, respectively. Histologic analysis parameters included tumor size, expression of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), and Ki-67, nuclear grade, histology subtype, and axillary lymph node (LN) metastasis. The relationships among SUVmax, ADC values, and pathologic prognostic factors were evaluated.The mean SUVmax and ADCmean were 5.63±3.79 (range, 1.2-24.17) and 894±204×10(-6)mm(2)/s (range, 452-1550×10(-6)), respectively. There was a significant but weak inverse correlation between the SUVmax and ADCmean values (correlation coefficient r=-0.30, p0.0001). SUVmax was associated with numerous prognostic factors such as tumor size (p0.0001), expression levels of ER (p=0.00041), PR (p=0.00028), HER2 (p=0.00021), and Ki-67 (p0.0001), nuclear grade (p0.0001), histology subtype (p=0.00061), axillary LN metastasis (p0.0001), and TNM staging (p0.0001). Meanwhile, ADCmean value was associated with tumor size (p=0.013), expression of Ki-67 (p=0.0010), histology subtype (p=0.00013), axillary LN metastasis (p=0.00059), and TNM staging (p=0.0011).Primary tumor SUVmax on FDG-PET/CT has a stronger relationship with known prognostic parameters and may be a more useful for predicting the prognosis of breast carcinoma than ADC values.
- Subjects :
- Adult
medicine.medical_specialty
Estrogen receptor
Breast Neoplasms
Multimodal Imaging
030218 nuclear medicine & medical imaging
Metastasis
03 medical and health sciences
0302 clinical medicine
Fluorodeoxyglucose F18
Positron Emission Tomography Computed Tomography
Progesterone receptor
medicine
Humans
Effective diffusion coefficient
Breast MRI
Whole Body Imaging
Radiology, Nuclear Medicine and imaging
Breast
Lymph node
Aged
Aged, 80 and over
medicine.diagnostic_test
business.industry
General Medicine
Middle Aged
Prognosis
medicine.disease
Primary tumor
Diffusion Magnetic Resonance Imaging
medicine.anatomical_structure
030220 oncology & carcinogenesis
Female
Radiology
Radiopharmaceuticals
Breast carcinoma
Nuclear medicine
business
Subjects
Details
- ISSN :
- 0720048X
- Volume :
- 85
- Database :
- OpenAIRE
- Journal :
- European Journal of Radiology
- Accession number :
- edsair.doi.dedup.....904be734764b4a6f68dcde2d0a2e131a