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Interferon-producing Cells Fail to Induce Proliferation of Naive T Cells but Can Promote Expansion and T Helper 1 Differentiation of Antigen-experienced Unpolarized T Cells
- Source :
- The Journal of Experimental Medicine
- Publication Year :
- 2003
- Publisher :
- Rockefeller University Press, 2003.
-
Abstract
- Interferon-producing cells (IPCs) secrete high levels of type I interferon in response to certain viruses. The lack of lineage markers, the expression of major histocompatibility complex (MHC) class II and the capacity to stimulate allogeneic T cells have led these cells to be classified as a subset of dendritic cells (DCs), called plasmacytoid DCs (PDCs). However, the role of IPCs/PDCs in initiating primary immune responses remains elusive. Here we examined the antigen presenting capacity of murine IPCs in antigen specific systems. While CD8α+ and CD11b+ DCs induced logarithmic expansion of naive CD4 and CD8 T cells, without conferring T helper commitment at a first encounter, primary IPCs lacked the ability to stimulate naive T cells. However, when antigen-experienced, nonpolarized T cells expanded by classical DC subsets, were restimulated by IPCs, they proliferated and produced high amounts of IFN-γ. These data indicate that IPCs can effectively stimulate preactivated or memory-type T cells and exert an immune-regulatory role. They also suggest that expansion of naive T cells and acquisition of effector function during antigen-specific T cell responses may involve different antigen-presenting cell (APC) types. Independent and coordinated control of T cell proliferation and differentiation would provide the immune system with greater flexibility in regulating immune responses.
- Subjects :
- Male
T-Lymphocytes
T cell
Immunology
Antigen presentation
Antigen-Presenting Cells
Biology
Lymphocyte Activation
Article
Mice
Interleukin 21
Leukocytes
medicine
Animals
Immunology and Allergy
Cytotoxic T cell
IL-2 receptor
Antigen-presenting cell
Cell Polarity
CD28
Cell Differentiation
Dendritic Cells
Th1 Cells
Natural killer T cell
Interleukin-12
Cell biology
medicine.anatomical_structure
Interferon Type I
Interleukin-2
interferon-producing cells
unpolarized T cells
Subjects
Details
- ISSN :
- 15409538 and 00221007
- Volume :
- 197
- Database :
- OpenAIRE
- Journal :
- Journal of Experimental Medicine
- Accession number :
- edsair.doi.dedup.....903fca8cd999e7432467f24b008b227a