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Effect of Monoenergetic Neutron Irradiation on the Postnatal Development of the Cochlea in C3H/HeN Mice
- Source :
- Journal of Veterinary Medical Science. 67:577-582
- Publication Year :
- 2005
- Publisher :
- Japanese Society of Veterinary Science, 2005.
-
Abstract
- To investigate the toxic effect of neutrons at energies of approximately 1MeV on the ear, we exposed 7-day-old mice to 1.0 Gy of monoenergetic neutrons (1.026 MeV) or (137)Cs gamma rays, and assessed subsequent morphological changes in the inner ear by light and scanning electron microscopy. Monoenergetic neutrons, but not gamma rays, caused acute changes in the ear. The epithelium of the greater epithelial ridge in the organ of Corti had disappeared by 72 hr post-irradiation, as a result of epithelial apoptosis observed 6 hr post-irradiation. Radiation could induce apoptotic cell death of the epithelium of the greater epithelial ridge at 3 or 4 days of age. Protruding structures were detected on the surface of the hair cells by 72 hr post-irradiation. The neutron-irradiation also caused the apoptotic cell death of epithelial cells at the nasal conchae, and subsequent acute otitis media continued until 10 weeks of age.
- Subjects :
- Pathology
medicine.medical_specialty
Acute otitis media
Apoptosis
Radiation
Epithelium
Mice
Radiation, Ionizing
otorhinolaryngologic diseases
medicine
Animals
Inner ear
Neutron irradiation
Cochlea
Neutrons
Mice, Inbred C3H
General Veterinary
Chemistry
Age Factors
Anatomy
medicine.anatomical_structure
Cesium Radioisotopes
Gamma Rays
Organ of Corti
Microscopy, Electron, Scanning
sense organs
Nasal Cavity
Subjects
Details
- ISSN :
- 13477439 and 09167250
- Volume :
- 67
- Database :
- OpenAIRE
- Journal :
- Journal of Veterinary Medical Science
- Accession number :
- edsair.doi.dedup.....903ac4a8bfd3a972f3daace07a827906