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Serotonin transporter-linked promoter region polymorphism and personality traits in a Japanese population
- Source :
- Neuroscience letters. 337(1)
- Publication Year :
- 2003
-
Abstract
- Serotonin transporter gene may play a critical role in a regulation of mood and other aspects of mental status. A large number of association studies have investigated a correlation between the polymorphism in the serotonin transporter-linked promoter region (5-HTTLPR) and anxiety-related personality traits. The results, however, have been inconsistent. Heterogeneity of subjects regarding gender, occupation, social-class and other environmental factors, in addition to effects of other genes, might have confounded the results. Here, we studied an association between the 5-HTTLPR polymorphism and personality traits in primarily female (78%) healthy subjects (n=244), who had homogeneous backgrounds regarding ethnicity (Japanese) and occupation. Personality traits of the subjects were assessed with the revised NEO Personality Inventory. No significant association was observed between the polymorphism and neuroticism or other personality traits, in all subjects, all females (n=190) or female nurses (n=159). Thus, our findings provided no evidence for an association between the 5-HTTLPR polymorphism and anxiety-related or other personality traits.
- Subjects :
- Adult
Male
Serotonin
Personality Inventory
media_common.quotation_subject
Nerve Tissue Proteins
Anxiety
Revised NEO Personality Inventory
Sex Factors
Asian People
Japan
mental disorders
Personality
Humans
Big Five personality traits
Promoter Regions, Genetic
Serotonin transporter
Genetic association
media_common
Genetics
Serotonin Plasma Membrane Transport Proteins
Membrane Glycoproteins
Polymorphism, Genetic
biology
General Neuroscience
Membrane Transport Proteins
Neuroticism
Mood
biology.protein
Female
Personality Assessment Inventory
Psychology
Carrier Proteins
Subjects
Details
- ISSN :
- 03043940
- Volume :
- 337
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Neuroscience letters
- Accession number :
- edsair.doi.dedup.....903729ea20a1904dc1dc0cd40d4277c0