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Bioinspired Therapeutic Dendrimers as Efficient Peptide Drugs Based on Supramolecular Interactions for Tumor Inhibition
- Source :
- Angewandte Chemie International Edition. 54:4289-4294
- Publication Year :
- 2015
- Publisher :
- Wiley, 2015.
-
Abstract
- Bioinspired tryptophan-rich peptide dendrimers (TRPDs) are designed as a new type of dendritic peptide drugs for efficient tumor therapy. The TRPDs feature a precise molecular structure and excellent water solubility and are obtained in a facile process. Based on the unique features of peptide dendrimers, including highly branched structures, abundant terminal groups, and globular-protein-like architectures, the therapeutic dendrimers show significant supramolecular interactions with DNA through the tryptophan residues (indole rings and amino groups). Further experimental results indicate that TRPDs are efficient antitumor agents both in vitro and in vivo.
- Subjects :
- Indole test
chemistry.chemical_classification
Dendrimers
Chemistry
Stereochemistry
Tumor inhibition
Supramolecular chemistry
Tryptophan
Antineoplastic Agents
Peptide
General Medicine
General Chemistry
Combinatorial chemistry
Catalysis
chemistry.chemical_compound
Microscopy, Electron, Transmission
Cell Line, Tumor
Neoplasms
Dendrimer
Humans
Molecule
Peptides
DNA
Subjects
Details
- ISSN :
- 14337851
- Volume :
- 54
- Database :
- OpenAIRE
- Journal :
- Angewandte Chemie International Edition
- Accession number :
- edsair.doi.dedup.....9030500117289a3fed2823328d13c68f