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Clinicopathologic factors for central recurrence in patients with locally advanced bulky cervical cancer

Authors :
Sang Young Ryu
Seok Cheol Choi
Beob Jong Kim
Eui Don Lee
Sang-Il Park
Moon Hong Kim
Won Moo Lee
Source :
European Journal of Obstetrics & Gynecology and Reproductive Biology. 161:219-223
Publication Year :
2012
Publisher :
Elsevier BV, 2012.

Abstract

Objective Locally advanced bulky cervical cancer (LABCC) is characterized by poor local control. The objective of this study was to identify the clinicopathologic variables associated with one-year central-only recurrence, which will serve as criteria for adjuvant hysterectomy after radiation (AHR) in patients with LABCC. Study design Between January 2000 and August 2007, we retrospectively evaluated outcomes in 225 patients with LABCC who were initially treated with radiation or chemoradiation. Results Among the 225 patients with LABCC, there were 41 recurrences within one year after treatment (8 central-only and 33 pelvis and/or distant site recurrences). Age, stage, and treatment type were not associated with the one-year central-only recurrences, but tumor size ≥8 cm had a statistically significant association based on multivariate analysis (OR, 5.39; 95% CI, 1.15–25.31; p = 0.03). The combination of non-squamous cell (non-SCC) type and tumor size ≥8 cm had a significantly higher rate of recurrence within one year (OR, 43.0; 95% CI, 4.78–386.68; p Conclusions Of patients with LABCC, those with non-SCC tumors ≥8 cm in size were at high risk for early central-only recurrence after cisplatin-based chemoradiation, and represent the subset of patients for whom AHR is beneficial.

Details

ISSN :
03012115
Volume :
161
Database :
OpenAIRE
Journal :
European Journal of Obstetrics & Gynecology and Reproductive Biology
Accession number :
edsair.doi.dedup.....902ee5617d18f0a28c9b8afbee23e75f
Full Text :
https://doi.org/10.1016/j.ejogrb.2011.12.029