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Clinicopathologic factors for central recurrence in patients with locally advanced bulky cervical cancer
- Source :
- European Journal of Obstetrics & Gynecology and Reproductive Biology. 161:219-223
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- Objective Locally advanced bulky cervical cancer (LABCC) is characterized by poor local control. The objective of this study was to identify the clinicopathologic variables associated with one-year central-only recurrence, which will serve as criteria for adjuvant hysterectomy after radiation (AHR) in patients with LABCC. Study design Between January 2000 and August 2007, we retrospectively evaluated outcomes in 225 patients with LABCC who were initially treated with radiation or chemoradiation. Results Among the 225 patients with LABCC, there were 41 recurrences within one year after treatment (8 central-only and 33 pelvis and/or distant site recurrences). Age, stage, and treatment type were not associated with the one-year central-only recurrences, but tumor size ≥8 cm had a statistically significant association based on multivariate analysis (OR, 5.39; 95% CI, 1.15–25.31; p = 0.03). The combination of non-squamous cell (non-SCC) type and tumor size ≥8 cm had a significantly higher rate of recurrence within one year (OR, 43.0; 95% CI, 4.78–386.68; p Conclusions Of patients with LABCC, those with non-SCC tumors ≥8 cm in size were at high risk for early central-only recurrence after cisplatin-based chemoradiation, and represent the subset of patients for whom AHR is beneficial.
- Subjects :
- Adult
Oncology
medicine.medical_specialty
medicine.medical_treatment
Uterine Cervical Neoplasms
Antineoplastic Agents
Kaplan-Meier Estimate
Adenocarcinoma
Hysterectomy
Disease-Free Survival
Carcinoma, Adenosquamous
Internal medicine
Confidence Intervals
Odds Ratio
Carcinoma
Humans
Medicine
Neoplasm Metastasis
Stage (cooking)
Aged
Neoplasm Staging
Proportional Hazards Models
Retrospective Studies
Aged, 80 and over
Cervical cancer
business.industry
Proportional hazards model
Obstetrics and Gynecology
Retrospective cohort study
Chemoradiotherapy
Odds ratio
Middle Aged
medicine.disease
Tumor Burden
Reproductive Medicine
Multivariate Analysis
Carcinoma, Squamous Cell
Female
Cisplatin
Neoplasm Recurrence, Local
business
Subjects
Details
- ISSN :
- 03012115
- Volume :
- 161
- Database :
- OpenAIRE
- Journal :
- European Journal of Obstetrics & Gynecology and Reproductive Biology
- Accession number :
- edsair.doi.dedup.....902ee5617d18f0a28c9b8afbee23e75f
- Full Text :
- https://doi.org/10.1016/j.ejogrb.2011.12.029