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Intracoronary shunt versus bulldog clamp in off-pump bypass surgery. Endothelial trauma: shunt versus clamp
- Source :
- The Journal of surgical research. 150(2)
- Publication Year :
- 2007
-
Abstract
- Background. During off-pump coronary bypass grafting, local vascular control of the target vessel and a bloodless field are crucial. The aim of this study is to asses the histopathological outcomes of intracoronary shunts and bulldog clamping on the beating heart in a canine model. Methods. Twelve healthy adult mongrel dogs weighing between 15 to 25 kg were included in the study. Following left thoracotomy, proximal left anterior descending artery segment 1 cm to distal of diagonal branch was marked. Arteriotomy at this site was performed and a shunt was inserted for 10 min in the shunt group. The bulldog clamp was applied 3 cm distal to the mark for 10 min after heparinization in the bulldog group. Thirty days after the procedure, the specimens of left anterior descending artery from both regions were collected and were examined. Vascular damage, presence of intimal hyperplasia, and denudation were noted. Results. Only intimal denudation was found significantly higher in the shunt group (P < 0.05). In this group, only one case had grade 0 endothelial damage. In the bulldog group, all cases had endothelial damage of various grades. Conclusion. The proven advantages of temporary intracoronary shunts are well-known, e.g., preserving the ventricular functions. Despite these advantages, our study revealed an ultimate bad result for an off-pump coronary by pass patient: intimal denudation. We conclude that further studies with a larger number of subjects are needed to decide whether routine shunt insertion into coronary arteries during off-pump coronary bypass surgery is appropriate or not.
- Subjects :
- Intimal hyperplasia
medicine.medical_treatment
Coronary Artery Bypass, Off-Pump
Injury
Artery clamp
Artery intima proliferation
Animal tissue
Surgical anastomosis
Midcab
Dog
Medicine
CABG
Priority journal
Occlusion
Off Pump Coronary Surgery
Coronary Artery Bypass Graft
Bypass Surgery
Surgical Instruments
Coronary Vessels
Off pump coronary surgery
medicine.anatomical_structure
Bypass surgery
Thoracotomy
Bulldog clamp
Blood vessel shunt
Target vessel
Shunt (electrical)
Artery
Endothelium injury
medicine.medical_specialty
Intraluminal shunts
Histopathology
Arteriotomy
Off-pump
Outcomes
Article
Dogs
Animals
Endothelium
Animal experiment
business.industry
Blood vessel injury
Left-ventricular function
Coronary-artery-bypass
medicine.disease
Nonhuman
Surgery
Coronary arteries
Clamp
Endothelium, Vascular
business
Controlled study
Shunts
Aorta clamping
Subjects
Details
- ISSN :
- 10958673
- Volume :
- 150
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- The Journal of surgical research
- Accession number :
- edsair.doi.dedup.....9022f45eb39d7d6d5100c9416f2faf7a