A new macrocyclic hexaamine ligand for the dissolution of human inorganic calculi

A newly synthesized 18-membered hexaamine carrying an acetate moiety on each nitrogen, L2, has been demonstrated to be a more efficient dissolving agent that ethylenediaminetetraacetic acid for human urinary calculi whose major components are calcium phosphate and magnesium phosphate. L2 is a good chelating agent for Ca2+ and Mg2+, and this chelating action is presumably responsible for the dissolution of inorganic calculi.