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The Effect of Metformin on Self-Selected Exercise Intensity in Healthy, Lean Males: A Randomized, Crossover, Counterbalanced Trial
- Source :
- Frontiers in Endocrinology, Frontiers in Endocrinology, Vol 12 (2021), Pilmark, N S, Petersen-Bønding, C, Holm, N F R, Johansen, M Y, Pedersen, B K, Hansen, K B & Karstoft, K 2021, ' The Effect of Metformin on Self-Selected Exercise Intensity in Healthy, Lean Males : A Randomized, Crossover, Counterbalanced Trial ', Frontiers in Endocrinology, vol. 12, 599164 . https://doi.org/10.3389/fendo.2021.599164
- Publication Year :
- 2021
- Publisher :
- Frontiers Media S.A., 2021.
-
Abstract
- IntroductionIn general, patients with type 2 diabetes have lower cardiorespiratory fitness levels and perform exercise at lower intensities compared to healthy controls. Since metformin (MET) has been shown to increase the rate of perceived exertion (RPE) during exercise with a fixed intensity, MET per se may reduce self-selected exercise intensity. The aim of this study was to assess the effect of MET on self-selected exercise intensity.MethodsHealthy males were eligible for this crossover, counterbalanced study with two treatment periods: MET and placebo (PLA), each lasting 17 days. Treatment dose was gradually increased and reached 2 g/day on treatment day 9, and continued at that level for the rest of the treatment period. The two periods were performed in randomized order. Two experimental days (A+B) were conducted on Day 15 (A) and Day 17 (B) of each period, respectively. Day A consisted of an exercise bout with self-selected exercise intensity (equal to RPE = 14–15 on the Borg Scale). Day B consisted of an exercise bout with fixed intensity (70% of VO2peak). Oxygen consumption rate was assessed continuously during both exercise bouts.ResultsFifteen males (age 23.7 ± 0.6 years, BMI 22.3 ± 2.0, VO2peak 3.5 ± 0.6 L/min) were included in the study. On Day B, RPE was higher in MET compared to PLA (14.8 ± 0.4 vs. 14.0 ± 0.3, P = 0.045). On Day A, no difference in self-selected exercise intensity measured by oxygen consumption rate (PLA 2.33 ± 0.09 L O2/min, MET 2.42 ± 0.10 L O2/min, P = 0.09) was seen between treatment periods.ConclusionsSelf-selected exercise intensity was not reduced by MET in healthy males, despite the fact that MET increased RPE during an exercise bout with fixed intensity.
- Subjects :
- Adult
Male
Endocrinology, Diabetes and Metabolism
Physical Exertion
030209 endocrinology & metabolism
Type 2 diabetes
030204 cardiovascular system & hematology
Placebo
lcsh:Diseases of the endocrine glands. Clinical endocrinology
03 medical and health sciences
Young Adult
0302 clinical medicine
Endocrinology
Oxygen Consumption
Medicine
Humans
rate of perceived exertion
lcsh:RC648-665
exercise
business.industry
Cardiorespiratory fitness
Brief Research Report
medicine.disease
Treatment period
Metformin
Intensity (physics)
Treatment dose
Diabetes Mellitus, Type 2
Anesthesia
Exercise intensity
self-selected exercise intensity
type 2 diabetes
business
metformin
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 16642392
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Frontiers in Endocrinology
- Accession number :
- edsair.doi.dedup.....90181881fcacac16960fcff15e9ce785