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Update: Clinical Use of Plasma Lactate
- Source :
- Veterinary Clinics of North America: Small Animal Practice. 47:325-342
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Lactate is an essential, versatile metabolic fuel in cellular bioenergetics. In human emergency and critical care, lactate is used as a biomarker and therapeutic endpoint and evidence is growing in veterinary medicine supporting its clinical utility. Lactate production is a protective response providing ongoing cellular energy during tissue hypoperfusion or hypoxia and mitigating acidosis. Hence, hyperlactatemia is closely associated with disease severity but it is an epiphenomenon as the body attempts to protect itself. This article reviews lactate biochemistry, kinetics, pathophysiology, some practical aspects of measuring lactate, as well as its use in diagnosis, prognosis, and monitoring.
- Subjects :
- medicine.medical_specialty
Bioenergetics
040301 veterinary sciences
0403 veterinary science
Sepsis
03 medical and health sciences
Dogs
0302 clinical medicine
Disease severity
Reference Values
Intensive care
Animals
Humans
Hyperlactatemia
Medicine
Dog Diseases
Lactic Acid
Small Animals
Intensive care medicine
Acidosis
business.industry
Septic shock
030208 emergency & critical care medicine
04 agricultural and veterinary sciences
Hypoxia (medical)
Prognosis
medicine.disease
medicine.symptom
business
Subjects
Details
- ISSN :
- 01955616
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Veterinary Clinics of North America: Small Animal Practice
- Accession number :
- edsair.doi.dedup.....90081567bd83a7ac8e4832886fe64120