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Digestive and genitourinary sequelae in rectal cancer survivors and their impact on health-related quality of life: Outcome of a high-resolution population-based study
- Source :
- Surgery, Surgery, Elsevier, 2019, 166, pp.327-335. ⟨10.1016/j.surg.2019.04.007⟩
- Publication Year :
- 2019
-
Abstract
- Background With the rising number of rectal cancer survivors, more patients with sphincter-preserving surgery are having to live with a potentially impaired quality of life. The survey aimed to assess bowel and genitourinary sequelae and their impact on quality of life in an unselected registry-based population of rectal cancer survivors. Methods This cross-sectional cohort survey (registered at ClinicalTrials.gov ; ID: NCT03459235 ) included patients with rectal cancer who underwent curative surgery with sphincter-preserving surgery from January 1, 2007 to January 31, 2015. Patients with recurrent disease, intestinal stoma, or cognitive disorders were excluded. Validated scoring system included the Urinary Symptom Profile in women and the International Prostate Symptom Score in men for urinary function, International Index for Erectile Function 5 in men and Female Sexual Function Index in women for sexual function, and Core 30/ Colo Rectal 29 questionnaires for quality of life and Low Anterior Resection Syndrome score for bowel function. The impact of functional sequelae on global quality of life was evaluated by multiple linear regression. Results Responders (45.3%, 92/203 patients) and nonresponders were comparable according to sex, age, tumor stage, and neoadjuvant chemoradiation. With a mean follow-up of 6.5 years, 65.2% of the rectal cancer survivors had bowel dysfunction, of whom 41.3% experienced major Low Anterior Resection Syndrome and 80% of rectal cancer survivors experienced genitourinary dysfunction. In multiple linear regression, poor bowel function was a significant predictor of global quality of life in men (P = .04) and women (P = .0003). Conclusion This survey highlights the importance of sexual and bowel dysfunction in rectal cancer survivors and the strong correlation between high Low Anterior Resection Syndrome score and inferior quality of life. Further studies are needed to improve knowledge on how to predict bowel dysfunction and how to best support patients with bowel dysfunction.
- Subjects :
- Male
medicine.medical_specialty
Cross-sectional study
Colorectal cancer
[SDV]Life Sciences [q-bio]
Digestive System Diseases
Population
030230 surgery
03 medical and health sciences
0302 clinical medicine
Quality of life
Cancer Survivors
Male Urogenital Diseases
Internal medicine
Surveys and Questionnaires
medicine
Humans
Registries
education
Aged
education.field_of_study
Genitourinary system
business.industry
Rectal Neoplasms
Middle Aged
medicine.disease
Combined Modality Therapy
Female Urogenital Diseases
3. Good health
Cross-Sectional Studies
030220 oncology & carcinogenesis
Population Surveillance
Cohort
Quality of Life
Surgery
International Prostate Symptom Score
Female
Sexual function
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 15327361 and 00396060
- Volume :
- 166
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Surgery
- Accession number :
- edsair.doi.dedup.....8fff65905aab51e9af4e7200d2d31a0f