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Cancer treatment and survival among cervical cancer patients living with or without HIV in South Africa
- Source :
- Turdo, Yannick Q; Ruffieux, Yann; Boshomane, Tebatso M G; Mouton, Hannes; Taghavi, Katayoun; Haas, Andreas D; Egger, Matthias; Maartens, Gary; Rohner, Eliane (2022). Cancer treatment and survival among cervical cancer patients living with or without HIV in South Africa. Gynecologic oncology reports, 43, p. 101069. Elsevier 10.1016/j.gore.2022.101069
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- Objective To compare cancer treatment and all-cause mortality between HIV-positive and HIV-negative cervical cancer patients in South Africa. Methods We assessed cancer treatment and all-cause mortality in HIV-positive and HIV-negative cervical cancer patients who received cancer treatment within 180 days of diagnosis using reimbursement claims data from a private medical insurance scheme in South Africa between 01/2011 and 07/2020. We assessed treatment provision using logistic regression and factors associated with all-cause mortality using Cox regression. We assigned missing values for histology and ethnicity using multiple imputation. Results Of 483 included women, 136 (28 %) were HIV-positive at cancer diagnosis (median age: 45.7 years), and 347 (72 %) were HIV-negative (median age: 54.1 years). Among 285 patients with available ICD-O-3 morphology claims codes, the proportion with cervical adenocarcinoma was substantially lower in HIV-positive (4 %) than in HIV-negative patients (26 %). Most HIV-positive patients (67 %) were on antiretroviral therapy at cancer diagnosis. HIV-positive patients were more likely to receive radiotherapy (adjusted odds ratio [aOR] 1.90, 95 % confidence interval [CI] 1.05-3.45) or chemotherapy (aOR 2.02, 95 %CI 0.92-4.43) and less likely to undergo surgery (aOR 0.53, 95 %CI 0.31-0.90) than HIV-negative patients. HIV-positive patients were at a higher risk of death from all causes than HIV-negative patients (adjusted hazard ratio 1.52, 95 %CI 1.06-2.19). Other factors associated with higher all-cause mortality included age > 60 years and metastases at diagnosis. Conclusions HIV-positive cervical cancer patients in South Africa had higher all-cause mortality than HIV-negative patients which could be explained by differences in tumour progression, clinical care, and HIV-specific mortality.
Details
- ISSN :
- 23525789
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- Gynecologic Oncology Reports
- Accession number :
- edsair.doi.dedup.....8fe094554a7d787f1ff3b8f6a8b1f456