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Brain and bone marrow metastases from rectal cancer
- Source :
- Annals of Gastroenterology
- Publication Year :
- 2019
- Publisher :
- Hellenic Society of Gastroenterology, 2019.
-
Abstract
- Despite the development of new treatment options based on the molecular characterization of colorectal cancer, 20% of patients present de novo metastatic disease, whereas 30-40% of patients who receive curative treatment relapse during follow up. Herein, we report 2 cases with rectal cancer that developed uncommon sites of metastasis; the first patient had an isolated breast metastasis, while the second patient developed bone marrow infiltration with synchronous brain metastases. In order to evaluate the uncommon metastatic pattern of rectal cancer, we detected and enumerated circulating tumor cells (CTCs) using both immunofluorescence and real-time reverse transcriptase polymerase chain reaction in these patients’ peripheral blood. The procedure revealed the presence of CTCs, positive for CEACAM5 but negative for epithelial phenotype (EpCAM-), that might explain the patients’ metastatic potential and survival.
- Subjects :
- 0301 basic medicine
Oncology
medicine.medical_specialty
Colorectal cancer
Case Report
Disease
circulating tumor cells
Immunofluorescence
law.invention
Metastasis
rare metastases
03 medical and health sciences
0302 clinical medicine
Circulating tumor cell
law
Internal medicine
medicine
Rectal cancer
Polymerase chain reaction
medicine.diagnostic_test
business.industry
Gastroenterology
medicine.disease
Reverse transcriptase
030104 developmental biology
medicine.anatomical_structure
030220 oncology & carcinogenesis
Bone marrow
business
Subjects
Details
- ISSN :
- 17927463
- Database :
- OpenAIRE
- Journal :
- Annals of Gastroenterology
- Accession number :
- edsair.doi.dedup.....8fe02f468a8158b0cee161b71a929803