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Effect of intravitreal bevacizumab for retinopathy of prematurity on weight gain
- Source :
- PLoS ONE, Vol 16, Iss 12, p e0261095 (2021), PLoS ONE, PLoS ONE, Vol 16, Iss 12 (2021)
- Publication Year :
- 2021
- Publisher :
- Public Library of Science (PLoS), 2021.
-
Abstract
- Purpose:To evaluate the short-term effect on body weight (BW) gain after intravitreal bevacizumab (IVB) for retinopathy of prematurity (ROP).<br />Methods:This was a retrospective 1:1 matched case-control study. Infants with ROP treated by IVB or photocoagulation (PC) at Shiga University of Medical Science Hospital between April 2010 and December 2019 were included in the study. To match BWs at treatment between the IVB and PC groups, 1:1 matching for BWs at treatment within 100 g was performed. The BW gains for the 7 days before treatment (pre-treatment week), the 7 days after treatment (first post-treatment week), and the period from 7 to 14 days after treatment (second post-treatment week) were compared between the IVB and PC groups.<br />Results:Following 1:1 matching, 13 infants in both groups were enrolled in the analysis. The weekly BW gain for the first post-treatment week was significantly lower in the IVB group compared with the PC group (86 g vs. 145 g; P = 0.046), whereas the weekly BW gains for the pre-treatment week (173 g vs. 159 g; P = 0.71) and the second post-treatment week (154 g vs. 152 g; P = 0.73) were comparable between the two groups. The short-term inhibitive effect of IVB on BW gain was particularly observed in infants weighing less than 1500 g at treatment (<br />Conclusion:IVB could have a short-term inhibitive effect on BW gain in infants with ROP, and this effect is more likely to occur in infants with a lower BW at the time of treatment.
- Subjects :
- Male
Time Factors
Eye Diseases
genetic structures
Physiology
Angiogenesis Inhibitors
Weight Gain
Families
Medical Conditions
Medicine and Health Sciences
Birth Weight
Children
Multidisciplinary
Body Fluids
Laboratory Equipment
Bevacizumab
Chemistry
Milk
Physiological Parameters
Research Design
Physical Sciences
Intravitreal Injections
Retinal Disorders
Engineering and Technology
Medicine
Female
Anatomy
Infants
Research Article
Chemical Elements
congenital, hereditary, and neonatal diseases and abnormalities
Clinical Research Design
Science
Ventilators
Equipment
Research and Analysis Methods
Beverages
Humans
Retinopathy of Prematurity
Retinopathy
Nutrition
Retrospective Studies
Body Weight
Biology and Life Sciences
Infant
eye diseases
Diet
Oxygen
Ophthalmology
Age Groups
Case-Control Studies
People and Places
Population Groupings
Adverse Events
sense organs
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- PLOS ONE
- Accession number :
- edsair.doi.dedup.....8fcf41ff4d1922b1ff9e33af0fcb1017