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Interferon-beta induces brain-derived neurotrophic factor in peripheral blood mononuclear cells of multiple sclerosis patients
- Source :
- Journal of Neuroimmunology, Vol. 197, No 2 (2008) pp. 147-51
- Publication Year :
- 2008
-
Abstract
- Interferon-beta (IFN-beta) achieves its beneficial effect on multiple sclerosis (MS) via anti-inflammatory properties. In this study, we assessed the expression of the brain-derived neurotrophic factor (BDNF) in peripheral blood mononuclear cells (PBMC) from relapsing-remitting multiple sclerosis (RRMS) patients treated or not with IFN-beta. Intracellular BDNF was measured by Western blot and ELISA and compared with serum BDNF. We found higher levels of BDNF in PBMC of IFN-beta-treated versus non-treated patients, whereas serum levels of BDNF were similar. We hypothesize that the increased intracellular BDNF secondary to IFN-beta is not released in the periphery. This release is probably not tissue specific but in MS patients, BDNF could be specifically delivered by PBMC at the site of re-activation, i.e. within the central nervous system.
- Subjects :
- Adult
Male
Multiple Sclerosis
Immunology
Central nervous system
Blotting, Western
Gene Expression Regulation/drug effects
Immunologic Factors/pharmacology
Enzyme-Linked Immunosorbent Assay
ddc:616.07
Peripheral blood mononuclear cell
Western blot
Neurotrophic factors
Blotting, Western/methods
medicine
Immunology and Allergy
Humans
Immunologic Factors
Leukocytes, Mononuclear/drug effects
Brain-derived neurotrophic factor
medicine.diagnostic_test
biology
Dose-Response Relationship, Drug
Enzyme-Linked Immunosorbent Assay/methods
business.industry
Multiple sclerosis
Brain-Derived Neurotrophic Factor
Interferon-beta
Middle Aged
Interferon-beta/pharmacology
Multiple Sclerosis/pathology
medicine.disease
ddc:616.8
Blot
medicine.anatomical_structure
nervous system
Neurology
Gene Expression Regulation
Case-Control Studies
biology.protein
Leukocytes, Mononuclear
Female
Neurology (clinical)
business
Brain-Derived Neurotrophic Factor/metabolism
Neurotrophin
Subjects
Details
- ISSN :
- 01655728
- Volume :
- 197
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of neuroimmunology
- Accession number :
- edsair.doi.dedup.....8fba45ac56193a299f817fe2176ef761