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Prognostic Values of Matrix Metalloproteinase Family Expression in Human Colorectal Carcinoma
- Source :
- Journal of Surgical Research. 146:32-42
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- We examined expression patterns of matrix metalloproteinase (MMP), tissue inhibitor of metalloproteinase (TIMP), and reversion-inducing cysteine-rich protein with Kazal motifs (RECK) in colorectal cancer tissues to assess their prognostic significance.mRNA expressions of 17 MMPs, 4 TIMPs, and RECK were measured in 112 colorectal cancerous tissues, 20 normal mucosa tissues, and 11 metastatic liver lesions by real-time reverse-transcriptional-polymerase chain reaction. The protein level expressions were confirmed with immunohistochemistry.Cancers and normal mucosa displayed highly significant differences (P0.01) in expression of nine genes (MMP-1, -3, -7, -9, -10, -11, -12, -14, and RECK). Primary cancers and metastatic lesions showed highly significant differences (P0.01) in MMP-1, -10, -11, and TIMP-1. MMP-12 expression was higher in the primary tumors that were associated without hepatic metastasis than those with metastasis (P0.01). High expression of MMP-15 was related to longer disease-free survival (generalized Wilcoxon test, P0.0062; Cox hazard model, P0.028, hazard ratio, 0.099).MMP, TIMP, RECK expression patterns may provide an insight into extracellular matrix degrading (which is characteristic of colorectal cancers) and its role in metastasis.
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
Colorectal cancer
Adenocarcinoma
Matrix metalloproteinase
GPI-Linked Proteins
Kazal Motifs
Disease-Free Survival
Metastasis
Extracellular matrix
Matrix Metalloproteinase 10
Matrix Metalloproteinase 11
Predictive Value of Tests
Humans
Medicine
RNA, Messenger
Aged
Proportional Hazards Models
Aged, 80 and over
Membrane Glycoproteins
business.industry
Liver Neoplasms
Matrix Metalloproteinase 15
Cancer
Tissue Inhibitor of Metalloproteinases
Middle Aged
Tissue inhibitor of metalloproteinase
Prognosis
medicine.disease
Matrix Metalloproteinases
Immunohistochemistry
Female
Surgery
Matrix Metalloproteinase 1
Neoplasm Recurrence, Local
Colorectal Neoplasms
business
Subjects
Details
- ISSN :
- 00224804
- Volume :
- 146
- Database :
- OpenAIRE
- Journal :
- Journal of Surgical Research
- Accession number :
- edsair.doi.dedup.....8fb0d2ddd3bb52edaa1ea0519fddcf97