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Isolation and structure elucidation of four new triterpenoid estersaponins from fruits of Pittosporum tobira ait
- Source :
- Tetrahedron. 58:10127-10136
- Publication Year :
- 2002
- Publisher :
- Elsevier BV, 2002.
-
Abstract
- Four new triterpenoid estersaponins, tentatively designated as IIIA2 ( 1 ), IIIA3 ( 2 ), IIIB2 ( 3 ), and IIIC4 ( 4 ) have been isolated from fruits of Pittosporum tobira ait . and their structures elucidated by spectroscopic and chemical analyses. All the four compounds consist of an acylated pentacyclic triterpenoid aglycone which bears the same oligosaccharide portion. The crude saponin mixture (CIDI) was found to show significant in vitro and in vivo cytotoxicity in different human cancer cell lines.
- Subjects :
- chemistry.chemical_classification
R1-barrigenol
biology
Stereochemistry
Organic Chemistry
Saponin
Pittosporum tobira ait. fruits
triterpenoid acylated saponins
reversed-phase HPLC
evaporative light scattering detector (ELSD)
anticancer drugs
Oligosaccharide
biology.organism_classification
Biochemistry
chemistry.chemical_compound
Aglycone
Triterpenoid
chemistry
Pentacyclic triterpenoid
Drug Discovery
In vivo cytotoxicity
Human cancer
Pittosporum tobira
Subjects
Details
- ISSN :
- 00404020
- Volume :
- 58
- Database :
- OpenAIRE
- Journal :
- Tetrahedron
- Accession number :
- edsair.doi.dedup.....8f9c0026f985782928b7b61d37eba1cb