Nanoluminal Signaling Shapes Collective Metastasis

Authors :: Valentin Gensbittel
Ignacio Busnelli
Jacky G. Goetz
Naël Osmani
Immuno-Rhumatologie Moléculaire
Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)
CCSD, Accord Elsevier
Source :: Trends in Cancer, Trends in Cancer, 2021, 7, pp.9-11. ⟨10.1016/j.trecan.2020.11.003⟩, Trends in Cancer, Cell Press, 2021, 7, pp.9-11. ⟨10.1016/j.trecan.2020.11.003⟩
Publication Year :: 2020
Abstract: Clustering of tumor cells is known to grant superior metastatic efficiency compared with single cells. However, the mechanisms involved remain elusive. Reporting in Cell, Wrenn et al. describe how sealed intercellular compartments, nanolumina, are used as growth factor reservoirs within tumor cell clusters to regulate tumor cell proliferation.