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Waiting time and mortality rate on lung transplant candidates in Japan: a single-center retrospective cohort study
- Source :
- BMC Pulmonary Medicine, Vol 21, Iss 1, Pp 1-9 (2021), BMC Pulmonary Medicine
- Publication Year :
- 2021
- Publisher :
- BMC, 2021.
-
Abstract
- Background As lung transplantation (LTX) is a valuable treatment procedure for end-stage pulmonary disease, delayed referral to a transplant center should be avoided. We aimed to conduct a single-center analysis of the survival time after listing for LTX and waitlist mortality in each disease category in a Japanese population. Methods We included patients listed for LTX at Tohoku University Hospital from January 2007 to December 2020 who were followed up until March 2021. Pulmonary disease was categorized into the Obstructive, Vascular, Suppurative, Fibrosis, and Allogeneic groups. Risk factors for waitlist mortality were assessed using a Cox proportional hazards model. The Kaplan–Meier method was used to model time to death. Results We included 269 LTX candidates. Of those, 100, 72, and 97 patients were transplanted, waiting, and dead, respectively. The median time to LTX and time to death were 796 days (interquartile range [IQR] 579–1056) and 323 days (IQR 129–528), respectively. The Fibrosis group showed the highest mortality (50.9%; p Conclusions In Japan, the waiting time is extremely long and candidates with Fibrosis have high mortality. There is a need to document outcomes based on the underlying disease for listed LTX candidates to help determine the optimal timing for listing patients based on the estimated local waiting time.
- Subjects :
- Adult
Lung Diseases
Male
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Waiting Lists
medicine.medical_treatment
Single Center
Time
Diseases of the respiratory system
Japan
Risk Factors
Interquartile range
Internal medicine
medicine
Humans
Lung transplantation
Mortality
Aged
Lung
Japan Organ Transplant Network
RC705-779
business.industry
Proportional hazards model
Research
Mortality rate
Hazard ratio
Retrospective cohort study
Waiting time
Middle Aged
medicine.anatomical_structure
Female
business
Subjects
Details
- Language :
- English
- ISSN :
- 14712466
- Volume :
- 21
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC Pulmonary Medicine
- Accession number :
- edsair.doi.dedup.....8f91d7dc6b26012ad5ec86498e5d91cd