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TUMOR CAPACITANCE: ELECTRICAL MEASUREMENTS OF RENAL NEOPLASIA
- Source :
- Journal of Urology. 172:454-457
- Publication Year :
- 2004
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2004.
-
Abstract
- Studies have demonstrated that biological tissues possess unique electrical properties. We evaluate the electrical properties of renal tumors using a specialized probe with the capability of measuring intra-tissue capacitance in an ex vivo model of fresh surgically excised tissue.An electrical monitoring device was used to measure tissue capacitance at a frequency of 1 MHz on 34 ex vivo kidney specimens freshly obtained after surgical excision. Tissue capacitance was promptly measured in the excised tumor as well as surrounding normal parenchyma and fat. Dielectric permittivity in each tissue was calculated using the measured capacitance data. These data were compared and correlated to pathological findings.The final pathology on the 34 specimens revealed 28 renal cell carcinomas (RCC), 3 oncocytomas and 3 angiomyolipomas. In patients with RCC dielectric permittivity of tumor tissue was 1.43 +/- 0.39 times greater than that of surrounding normal parenchyma (p0.001). The average tumor-to-normal tissue dielectric permittivity ratio for RCC was significantly greater than that for angiomyolipoma (1.43 +/- 0.39 vs 0.73 +/- 0.77, p0.05) but similar to that for oncocytoma (1.43 +/- 0.39 vs 1.63 +/- 0.77, p = 0.39).Tissue capacitance measurements may be used to differentiate renal tumor from surrounding normal tissue. In vivo studies will ultimately determine the clinical use of this technology in localizing renal neoplasms and differentiating between malignant and benign tissues.
- Subjects :
- Adult
Male
Nephrology
medicine.medical_specialty
Pathology
Adenoma
Urology
Angiomyolipoma
Electric Capacitance
Renal neoplasm
In vivo
Internal medicine
Parenchyma
medicine
Adenoma, Oxyphilic
Humans
Carcinoma, Renal Cell
Aged
Aged, 80 and over
Kidney
business.industry
Middle Aged
medicine.disease
Kidney Neoplasms
medicine.anatomical_structure
Female
business
Ex vivo
Subjects
Details
- ISSN :
- 15273792 and 00225347
- Volume :
- 172
- Database :
- OpenAIRE
- Journal :
- Journal of Urology
- Accession number :
- edsair.doi.dedup.....8f8447e5fd862a71f869cfee9567c39b