Are biologics for chronic rhinosinusitis effective and safe?

Chronic rhinosinusitis (CRS) refers to inflammation of the nasal sinuses and mucosa, with persistence of sinus inflammation and clinical manifestations beyond 12 weeks.1 CRS affects between 6 and 12% of adults and is a cause of reduced quality of life (QoL) and high healthcare costs.2 Management consisted of topical and systemic glucocorticoids, antibiotics and often repeated sinus surgery. Over the past 20 years, biologic therapies under investigation for asthma, with overlapping nasal polyposis, have shown significant improvement in sinonasal CRS symptoms and reduced nasal polyp swelling.3 This Cochrane Corner aims to summarize the effectiveness, safety and role of biological therapy in CRS to aid clinicians in the decision-making process.