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A novel rodent papillomavirus isolated from anogenital lesions in its natural host
- Source :
- Virology. (1):186-197
- Publisher :
- Elsevier Inc.
-
Abstract
- In the present work we describe both the prevalence and the histopathologic features of a novel papillomavirus (referred as McPV2) that naturally infects the rodent Mastomys coucha. Viral DNA could be isolated not only from anogenital wart-like lesions but also from healthy tissues (e.g. liver, kidney, spleen and intestine) without apparent signs of infection. Our finding of a second papillomavirus infecting M. coucha, phylogenetically very distant from the previously known MnPV, reinforces the growing view of warm-blooded vertebrates as being hosts for a number of different papilloma virus types that are not necessarily closely related. The histological descriptions of McPV2-associated anogenital lesions provided here, together with earlier knowledge on MnPV-associated skin carcinogenesis, define M. coucha as an excellent system where the link between infection towards malignancy can be studied in molecular, histochemical and immunological terms in immunocompetent animals. The availability of such an in vivo model also offers the unique opportunity to address defined questions about prophylactic and therapeutic strategies against different papillomavirus infections in their natural host. To date, McPV2 is the first rodent papillomavirus found in anogenital lesions.
- Subjects :
- Rodent Diseases
Mastomys coucha
Rodent
Anal Canal
Spleen
Condyloma
Malignancy
medicine.disease_cause
Kidney
biology.animal
Virology
medicine
Animals
Genitalia
Papillomaviridae
Phylogeny
biology
Papillomavirus Infections
MnPV
Murinae
Sequence Analysis, DNA
medicine.disease
biology.organism_classification
Intestines
Skin carcinogenesis
medicine.anatomical_structure
Liver
Immunology
DNA, Viral
Warts
Carcinogenesis
Subjects
Details
- Language :
- English
- ISSN :
- 00426822
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Virology
- Accession number :
- edsair.doi.dedup.....8f7ec5cee78bb198a268100ffdd856b6
- Full Text :
- https://doi.org/10.1016/j.virol.2007.12.012