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The effects of different dosage levels of hepatitis B vaccine as booster on anti-HBs-negative children 5-15 y after primary immunization; China, 2009-2010
- Source :
- Human Vaccines & Immunotherapeutics
- Publication Year :
- 2013
-
Abstract
- The changes in lgG antibody levels to hepatitis B surface antigen (HBsAg) and in antibody to HBsAg (anti-HBs) seroconversion rates due to different dosages of hepatitis B vaccine (HepB) were compared in 2106 children. Children who had been previously vaccinated as infants with HepB were revaccinated at 5–15 y of age, after which the antibody titers were determined. After the first booster dose, the anti-HBs seroconversion rate (defined as an anti-HBs ≥10 mIU/ml) with 10 μg of HepB (93.6%) was significantly greater than the rate with 5 µg of HepB (90.3%) (P < 0.05); the anti-HBs seroconversion rate in 10–15-y-old boys vaccinated with 10 μg of HepB (90.9%) was significantly greater than the rate with 5 µg of HepB (84.3%) (P < 0.05). The anti-HBs seroconversion rates after the third booster dose with 5 or 10 μg of HepB were greater than those after the first booster dose (99.6% and 99.7%, vs. 90.3% and 93.6%, P < 0.05); as was the corresponding GMTs (658 ± 4 mIU/ml and 2599 ± 3 mIU/ml, vs. 255 ± 11 mIU/ml and 877 ± 11 mIU/ml [P < 0.05]). The immunization effects of booster vaccination with 3 doses of HepB with 5 or 10 µg are effective; a single booster dose with 10 µg of HepB for 10–15-y-old boys and with 5 or 10 µg of HepB for 5–9 y old boys and for 5–15-y-old girls are effective in generating protective antibody against HBV; however, for anti-HBs-negative children after a single dose of booster, 3 doses are needed.
- Subjects :
- Male
medicine.medical_specialty
HBsAg
China
Hepatitis B vaccine
Dose
Adolescent
Immunology
Dose-Response Relationship, Immunologic
Immunization, Secondary
Booster dose
Gastroenterology
different dosages
Internal medicine
medicine
Immunology and Allergy
Humans
Hepatitis B Vaccines
Seroconversion
Hepatitis B Antibodies
Child
Pharmacology
Booster (rocketry)
business.industry
effect
Antibody titer
Hepatitis B
medicine.disease
booster vaccination
Child, Preschool
Immunoglobulin G
Female
business
hepatitis B vaccine
Research Paper
Subjects
Details
- ISSN :
- 2164554X
- Volume :
- 10
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Human vaccinesimmunotherapeutics
- Accession number :
- edsair.doi.dedup.....8f7b3b3a08e0ef81bf1f46a36f274427