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Genetic trace metal disturbances
- Source :
- Journal of the American College of Nutrition. 4:39-48
- Publication Year :
- 1985
- Publisher :
- Informa UK Limited, 1985.
-
Abstract
- Genetic trace metal disturbances can be at three levels. Trace metals play an important role in the metabolism of genetic macromolecules and the information transfer system. Deficiency or excess of trace metals caused either by dietary or genetic factors will affect the normal functioning of the whole organism. The roles of trace metals in carcinogenesis/mutagenesis and ageing are typical of this category. The second level of genetic trace metal disturbances affect the metabolic pathway of the trace metal itself. Biochemical derangement resulting from genetic defects cause aberrant metabolism of the element and thus disease symptoms. Diseases caused by abnormal metabolism of copper, zinc, iron, and molybdenum are discussed. Trace metal disturbances can also be the result of other genetic diseases. This aspect of genetic trace metal disturbances is least investigated. However, information should be important for improving the existing treatment protocol for the more common inborn errors of metabolism, such as phenylketonuria.
- Subjects :
- Male
Molybdenum
Nutrition and Dietetics
Iron
Genetic Diseases, Inborn
Proteins
Medicine (miscellaneous)
DNA
Biology
Rats
Trace Elements
Trace (semiology)
Zinc
Normal functioning
Metabolic pathway
RNA, Transfer
Biochemistry
Protein Biosynthesis
Existing Treatment
Animals
Humans
RNA
Trace metal
Copper
Metal Metabolism, Inborn Errors
Subjects
Details
- ISSN :
- 15411087 and 07315724
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of the American College of Nutrition
- Accession number :
- edsair.doi.dedup.....8f786a4615accdc7409b0cf045e195ec