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Richness of human gut microbiome correlates with metabolic markers
- Source :
- Le Chatelier, E, Nielsen, T, Qin, J, Prifti, E, Hildebrand, F, Falony, G, Almeida, M, Arumugam, M, Batto, J-M, Kennedy, S, Leonard, P, Li, J, Burgdorf, K, Grarup, N, Jørgensen, T, Brandslund, I, Nielsen, H B, Juncker, A S, Bertalan, M, Levenez, F, Pons, N, Rasmussen, S, Sunagawa, S, Tap, J, Tims, S, Zoetendal, E G, Brunak, S, Clément, K, Doré, J, Kleerebezem, M, Kristiansen, K, Renault, P, Sicheritz-Ponten, T, de Vos, W M, Zucker, J-D, Raes, J, Hansen, T, Guedon, E, Delorme, C, Layec, S, Khaci, G, van de Guchte, M, Vandemeulebrouck, G, Jamet, A, Dervyn, R, Sanchez, N, Maguin, E, Haimet, F, Winogradski, Y, Cultrone, A, Leclerc, M, Juste, C, Blottière, H, Pelletier, E, LePaslier, D, Artiguenave, F, Bruls, T, Weissenbach, J, Turner, K, Parkhill, J, Antolin, M, Manichanh, C, Casellas, F, Boruel, N, Varela, E, Torrejon, A, Guarner, F, Denariaz, G, Derrien, M, van Hylckama Vlieg, J E T, Veiga, P, Oozeer, R, Knol, J, Rescigno, M, Brechot, C, M’Rini, C, Mérieux, A, Yamada, T, Bork, P, Wang, J, Ehrlich, S D & Pedersen, O 2013, ' Richness of human gut microbiome correlates with metabolic markers ', Nature, vol. 500, no. 7464, pp. 541-546 . https://doi.org/10.1038/nature12506, Nature; Vol 500, Nature 500 (2013) 7464, Nature, Nature, Nature Publishing Group, 2013, 500 (7464), pp.541-546. ⟨10.1038/nature12506⟩, Nature, Nature Publishing Group, 2013, 500 (7464), pp.541-546. 〈10.1038/nature12506〉, Le Chatelier, E, Nielsen, T, Qin, J, Prifti, E, Hildebrand, F, Falony, G, Almeida, M, Arumugam, M, Batto, J-M, Kennedy, S, Leonard, P, Li, J, Burgdorf, K S, Grarup, N, Jørgensen, T, Brandslund, I, Nielsen, H B, Juncker, A, Bertalan, M, Levenez, F, Pons, N, Rasmussen, S, Sunagawa, S, Tap, J, Tims, S, Zoetendal, E G, Brunak, S, Clément, K, Doré, J, Kleerebezem, M, Kristiansen, K, Renault, P, Sicheritz-Ponten, T, de Vos, W M, Zucker, J-D, Raes, J, Hansen, T, Bork, P, Wang, J, Ehrlich, S D, Pedersen, O B & MetaHIT consortium 2013, ' Richness of human gut microbiome correlates with metabolic markers ', Nature Communications, vol. 500, no. 7464, pp. 541-546 . https://doi.org/10.1038/nature12506, Nature, 500(7464), 541-546, Nature, 2013, 500 (7464), pp.541-546. ⟨10.1038/nature12506⟩
- Publication Year :
- 2013
-
Abstract
- We are facing a global metabolic health crisis provoked by an obesity epidemic. Here we report the human gut microbial composition in a population sample of 123 non-obese and 169 obese Danish individuals. We find two groups of individuals that differ by the number of gut microbial genes and thus gut bacterial richness. They contain known and previously unknown bacterial species at different proportions; individuals with a low bacterial richness (23% of the population) are characterized by more marked overall adiposity, insulin resistance and dyslipidaemia and a more pronounced inflammatory phenotype when compared with high bacterial richness individuals. The obese individuals among the lower bacterial richness group also gain more weight over time. Only a few bacterial species are sufficient to distinguish between individuals with high and low bacterial richness, and even between lean and obese participants. Our classifications based on variation in the gut microbiome identify subsets of individuals in the general white adult population who may be at increased risk of progressing to adiposity-associated co-morbidities.
- Subjects :
- Male
[SDV]Life Sciences [q-bio]
body-mass index
Overweight
Weight Gain
Body Mass Index
0302 clinical medicine
Microbiologie
insulin resistance
Phylogeny
2. Zero hunger
0303 health sciences
education.field_of_study
adiposity
Multidisciplinary
reared apart
Ecology
twins
3. Good health
Europe
030220 oncology & carcinogenesis
Enterotype
Biological Markers
Female
medicine.symptom
weight-loss
Adult
diet-induced obesity
Population
European Continental Ancestry Group
Zoology
body mass index
wide association
Biology
Microbiology
White People
insulin-resistance
03 medical and health sciences
Thinness
diet induced obesity
Weight Loss
medicine
Humans
Microbiome
Host-Microbe Interactomics
Obesity
education
030304 developmental biology
VLAG
Dyslipidemias
disease
Bacteria
[ SDV ] Life Sciences [q-bio]
medicine.disease
Diet
Gastrointestinal Tract
Metagenomics
Genes, Bacterial
inflammation
Case-Control Studies
WIAS
Metagenome
Species richness
Insulin Resistance
weight loss
Energy Metabolism
Weight gain
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 00280836, 14764679, and 14764687
- Database :
- OpenAIRE
- Journal :
- Le Chatelier, E, Nielsen, T, Qin, J, Prifti, E, Hildebrand, F, Falony, G, Almeida, M, Arumugam, M, Batto, J-M, Kennedy, S, Leonard, P, Li, J, Burgdorf, K, Grarup, N, Jørgensen, T, Brandslund, I, Nielsen, H B, Juncker, A S, Bertalan, M, Levenez, F, Pons, N, Rasmussen, S, Sunagawa, S, Tap, J, Tims, S, Zoetendal, E G, Brunak, S, Clément, K, Doré, J, Kleerebezem, M, Kristiansen, K, Renault, P, Sicheritz-Ponten, T, de Vos, W M, Zucker, J-D, Raes, J, Hansen, T, Guedon, E, Delorme, C, Layec, S, Khaci, G, van de Guchte, M, Vandemeulebrouck, G, Jamet, A, Dervyn, R, Sanchez, N, Maguin, E, Haimet, F, Winogradski, Y, Cultrone, A, Leclerc, M, Juste, C, Blottière, H, Pelletier, E, LePaslier, D, Artiguenave, F, Bruls, T, Weissenbach, J, Turner, K, Parkhill, J, Antolin, M, Manichanh, C, Casellas, F, Boruel, N, Varela, E, Torrejon, A, Guarner, F, Denariaz, G, Derrien, M, van Hylckama Vlieg, J E T, Veiga, P, Oozeer, R, Knol, J, Rescigno, M, Brechot, C, M’Rini, C, Mérieux, A, Yamada, T, Bork, P, Wang, J, Ehrlich, S D & Pedersen, O 2013, ' Richness of human gut microbiome correlates with metabolic markers ', Nature, vol. 500, no. 7464, pp. 541-546 . https://doi.org/10.1038/nature12506, Nature; Vol 500, Nature 500 (2013) 7464, Nature, Nature, Nature Publishing Group, 2013, 500 (7464), pp.541-546. ⟨10.1038/nature12506⟩, Nature, Nature Publishing Group, 2013, 500 (7464), pp.541-546. 〈10.1038/nature12506〉, Le Chatelier, E, Nielsen, T, Qin, J, Prifti, E, Hildebrand, F, Falony, G, Almeida, M, Arumugam, M, Batto, J-M, Kennedy, S, Leonard, P, Li, J, Burgdorf, K S, Grarup, N, Jørgensen, T, Brandslund, I, Nielsen, H B, Juncker, A, Bertalan, M, Levenez, F, Pons, N, Rasmussen, S, Sunagawa, S, Tap, J, Tims, S, Zoetendal, E G, Brunak, S, Clément, K, Doré, J, Kleerebezem, M, Kristiansen, K, Renault, P, Sicheritz-Ponten, T, de Vos, W M, Zucker, J-D, Raes, J, Hansen, T, Bork, P, Wang, J, Ehrlich, S D, Pedersen, O B & MetaHIT consortium 2013, ' Richness of human gut microbiome correlates with metabolic markers ', Nature Communications, vol. 500, no. 7464, pp. 541-546 . https://doi.org/10.1038/nature12506, Nature, 500(7464), 541-546, Nature, 2013, 500 (7464), pp.541-546. ⟨10.1038/nature12506⟩
- Accession number :
- edsair.doi.dedup.....8f6fb96ab4568e9cdd3b9d1d17959498
- Full Text :
- https://doi.org/10.1038/nature12506