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The VEGF and PEDF levels in the follicular fluid of patients co- treated with LETROZOLE and gonadotropins during the stimulation cycle
- Source :
- Reproductive Biology and Endocrinology, Vol 16, Iss 1, Pp 1-5 (2018), Reproductive Biology and Endocrinology : RB&E
- Publication Year :
- 2018
- Publisher :
- BMC, 2018.
-
Abstract
- Background Previous studies have shown that androgens, in addition to serving as precursors for ovarian estrogen synthesis, also have a fundamental role in primate ovarian follicular development by augmentation of FSH receptor expression on granulosa cells. Recent studies have shown that aromatase inhibitor, letrozole, improves ovarian response to FSH in normal and poor responder patients, possibly by increasing intraovarian androgen levels. Studies in mice also showed an effect of letrozole to increase pigment epithelium-derived factor (PEDF) and to lower vascular epithelial growth factor (VEGF), which might be expected to reduce the risk of ovarian hyperstimulation syndrome (OHSS) with stimulation. The aim of this study was to compare the VEGF and PEDF levels in the follicular fluids of normal responders treated with letrozole and gonadotropins during the ovarian stimulation with patients treated with gonadotropins only. Methods A single center, prospective clinical trial. We collected follicular fluid from 26 patients, on a GnRH antagonist protocol, dual triggered with hCG and GnRH agonist. The patients in one group were co-treated with letrozole and gonadotropins during the ovarian stimulation and the patients in the other group were treated with gonadotropins only. VEGF, PEDF, estrogen, progesterone and testosterone levels were measured by ELISA kits. Results The age of the patients, the total dose of gonadotropins and the number of oocytes were comparable between the two groups. In the follicular fluid, the estrogen levels (2209 nmol/l vs. 3280 nmol/l, p = 0.02) were significantly decreased, and the testosterone levels (246.5 nmol/l vs. 40.7 nmol/l, p
- Subjects :
- Male
Vascular Endothelial Growth Factor A
0301 basic medicine
Ovarian hyperstimulation syndrome
0302 clinical medicine
Endocrinology
Pregnancy
Follicular phase
lcsh:Reproduction
Prospective Studies
030219 obstetrics & reproductive medicine
Aromatase Inhibitors
Letrozole
Obstetrics and Gynecology
Drug Therapy, Combination
Female
Gonadotropin
Infertility, Female
medicine.drug
Adult
medicine.medical_specialty
endocrine system
lcsh:QH471-489
medicine.drug_class
lcsh:Gynecology and obstetrics
03 medical and health sciences
PEDF
Ovulation Induction
Internal medicine
Nitriles
medicine
Humans
Nerve Growth Factors
Eye Proteins
Serpins
lcsh:RG1-991
Aromatase inhibitor
business.industry
Research
VEGF. PEDF
Triazoles
medicine.disease
Follicular fluid
Follicular Fluid
030104 developmental biology
Reproductive Medicine
Estrogen
business
Gonadotropins
Developmental Biology
Subjects
Details
- Language :
- English
- ISSN :
- 14777827
- Volume :
- 16
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Reproductive Biology and Endocrinology
- Accession number :
- edsair.doi.dedup.....8f601ad46606d013f2b73c98c6adc59b