Systemic and Coronary Hemodynamic Effects of 2 Amino-4-Methyl Pyridine

Conclusion1. The systemic and coronary hemodynamic effects of Ascensil®. (2-amino-4-methyl pyridine) also known as RA 1226 and in the German literature as W 45, has been investigated in 10 mongrel dogs. 2. Its administration has been associated with a marked increase in peripheral, pulmonary and coronary vascular resistance accompanied by an increase in peripheral arterial and right atrial pressure. 3. Considerable reduction occurred in cardiac output, coronary blood flow and myocardial oxygen usage per 100 g per minute, subsequent to its administration. 4. Calculated cardiac efficiency, body oxygen consumption, total body respiratory quotient and cardiac respiratory quotients were unchanged.