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The Role of Efferocytosis in Atherosclerosis
- Publication Year :
- 2017
-
Abstract
- The necrotic core has long been a hallmark of the vulnerable atherosclerotic plaque. Although apoptotic cells are cleared quickly in almost all other tissue beds, their removal appears to be significantly impaired in the diseased blood vessel. Emerging evidence indicates that this phenomenon is caused by a defect in efferocytosis, the process by which apoptotic tissue is recognized for engulfment by phagocytic cells such as macrophages. Genetic and experimental data suggest that efferocytosis is impaired during atherogenesis caused by dysregulation of so-called eat me ligands, which govern the edibility of cells undergoing programmed cell death. The following is a summary of recent data indicating that efferocytosis is a major unappreciated driver of lesion expansion but also a reversible defect that can potentially be targeted as a means to prevent plaque progression.
- Subjects :
- 0301 basic medicine
Programmed cell death
Necrotic core
business.industry
Macrophages
Apoptosis
Atherosclerosis
Article
Lesion
03 medical and health sciences
030104 developmental biology
medicine.anatomical_structure
Phagocytosis
Physiology (medical)
Immunology
medicine
Macrophage
Humans
medicine.symptom
Cardiology and Cardiovascular Medicine
Efferocytosis
business
Clearance
Blood vessel
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....8f539d7ad33aab9222067c1f166d7052