Back to Search
Start Over
Inter-relationship between platelet-derived microparticles and oxidative stress in patients with venous thromboembolism
- Source :
- Antioxidants, Volume 9, Issue 12, Antioxidants, Vol 9, Iss 1217, p 1217 (2020)
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- Background: Hypercoagulative conditions play a key role in venous thromboembolism (VTE). Inflammation is currently linked to VTE, but the potential role of circulating microparticles and oxidative stress (OxS) must be elucidated. The aim of this study was to evaluate platelet-derived microparticles and surrogate OxS biomarkers in patients diagnosed with VTE through a case&ndash<br />control study. Methods: Platelet-derived microparticles (MPs), pro-thrombinase-induced clotting time assay (PiCT), phospholipids (PLPs), malondialdehyde (MDA), 4-hydroxynonenale (4-HNE), thiobarbituric acid reactive substances (TBARs), superoxide dismutase (SOD), and galectin-3 (Gal-3) were measured in VTE patients and in healthy controls. Results: PLPs, 4-HNE, TBARs, and Gal-3 were higher in VTE patients compared to controls<br />conversely, SOD was lower. A significant non-linear regression between OxS biomarkers and the markers of platelet degranulation was found. Conclusion: Our results suggest that OxS and platelet degranulation are concomitant pathophysiological mechanisms in VTE.
- Subjects :
- medicine.medical_specialty
Physiology
Thiobarbituric acid
venous thromboembolism
Clinical Biochemistry
030204 cardiovascular system & hematology
medicine.disease_cause
Biochemistry
Gastroenterology
Pathophysiology
Article
Superoxide dismutase
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Platelet degranulation
Internal medicine
medicine
TBARS
oxidative stress
Platelet
cardiovascular diseases
030212 general & internal medicine
Molecular Biology
microparticles
Venous thromboembolism
biology
business.industry
lcsh:RM1-950
biomarkers
Cell Biology
Biomarker
equipment and supplies
Malondialdehyde
lcsh:Therapeutics. Pharmacology
Clotting time
chemistry
Microparticle
platelets
biology.protein
Oxidative stre
business
Oxidative stress
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Antioxidants, Volume 9, Issue 12, Antioxidants, Vol 9, Iss 1217, p 1217 (2020)
- Accession number :
- edsair.doi.dedup.....8f4a504d84d41363373e07c993e6e084