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Impact of Exercise Capacity on Myocardial High-Energy Phosphate Metabolism

Authors :
Pachinger O
Werner Jaschke
Ralf H. Zwick
Michael Schocke
Matthias Frick
E. Conci
Bernhard Metzler
Gert Klug
Christian Wolf
Source :
International Journal of Sports Medicine. 28:667-672
Publication Year :
2007
Publisher :
Georg Thieme Verlag KG, 2007.

Abstract

31-Phosphorous magnetic resonance spectroscopy (31P MRS) is a unique tool to investigate IN VIVO high-energy phosphates (HEP) in the human heart. We hypothesized that physical capacity may be associated with myocardial HEP status. Healthy, male volunteers (n = 105, mean age 51 +/- 7 years) underwent bicycle ergometry with a stepwise increasing workload to determine maximal working capacity (MWC). Heart rate (HR) and blood pressure (BP) were measured continuously during exercise and 4 minutes of recovery. Further 31-Phosphorous 2-dimensional chemical shift imaging (31P 2D CSI) MRS was performed to assess myocardial HEP metabolism by determining phosphocreatinine to beta-ATP ratios (PCr/b-ATP) using a 1.5 tesla scanner. Volunteers with MWC230 Watt had significantly higher PCr/b-ATP ratios than those with MWC200 Watt (1.93 +/- 0.36 vs. 1.59 +/- 0.35; p0.001). Additionally, those with a recovery systolic (S)BP195 mmHg had significantly higher ratios than those with a recovery SBP195 mmHg (1.74 +/- 0.3 vs. 1.51 +/- 0.2; p0.05). We observed a linear correlation between the PCr/b-ATP ratio and MWC (r = 0.411; p0.001) and recovery SBP (r = - 0.290; p0.01). After statistical correction for age, these correlations remained significant. In this study, we observed a correlation of parameters of physical fitness determined by bicycle exercise testing and cardiac PCr/b-ATP ratios.

Details

ISSN :
14393964 and 01724622
Volume :
28
Database :
OpenAIRE
Journal :
International Journal of Sports Medicine
Accession number :
edsair.doi.dedup.....8f47f192c67e427c43c11d3c5b8561ef
Full Text :
https://doi.org/10.1055/s-2007-964862