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Efficacy and safety of two single-pill fixed-dose combinations of angiotensin II receptor blockers/calcium channel blockers in hypertensive patients (EXAMINER study)
- Source :
- Clinical and experimental hypertension (New York, N.Y. : 1993). 38(1)
- Publication Year :
- 2015
-
Abstract
- There is some controversy regarding which single-pill fixed-dose combinations of angiotensin II type 1 receptor blockers (ARBs) and calcium channel blockers (CCBs) are effective at reducing blood pressure (BP).Sixty hypertensive patients who received a single-pill fixed-dose combination of valsartan 80 mg/day and amlodipine 5 mg/day were enrolled (UMIN Registration 000013460). They were randomly divided into two treatment groups [single-pill fixed-dose combination therapy with valsartan 80 mg/day and amlodipine 5 mg/day (Val/Am group), or irbesartan 100 mg/day and amlodipine 5 mg/day (Irb/Am group)] and treated for 16 weeks. If the patient did not reach the target office BP at 8 weeks, they received double doses of amlodipine (10 mg/day).In the Irb/Am group, systolic BP (SBP) and diastolic BP (DBP) were significantly decreased at 16 weeks. There were no significant changes in SBP or DBP in the Val/Am group. In the Irb/Am group, serum uric acid (UA) was significantly decreased at 8 weeks and patients who had hyperuricemia showed significantly decreased serum UA at 16 weeks. In addition, the levels of triglycerides (TG) were significantly decreased at 16 weeks in the Irb/Am group.A single-pill fixed-dose combination therapy with irbesartan 100 mg/day and amlodipine 5 mg/day was superior to the combination of valsartan 80 mg/day and amlodipine 5 mg/day with respect to significant decreases in BP, serum UA and TG in patients with hypertension.
- Subjects :
- Male
medicine.medical_specialty
Combination therapy
Physiology
Diastole
Urology
Tetrazoles
Blood Pressure
030204 cardiovascular system & hematology
Pharmacology
03 medical and health sciences
0302 clinical medicine
Irbesartan
Internal Medicine
Medicine
Humans
Amlodipine
Antihypertensive Agents
Triglycerides
Aged
Dose-Response Relationship, Drug
business.industry
Calcium channel
Biphenyl Compounds
General Medicine
Middle Aged
Uric Acid
Biphenyl compound
Drug Combinations
Blood pressure
Treatment Outcome
Valsartan
Hypertension
Female
Drug Monitoring
business
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- ISSN :
- 15256006
- Volume :
- 38
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Clinical and experimental hypertension (New York, N.Y. : 1993)
- Accession number :
- edsair.doi.dedup.....8f40615cfd5e97160838254918bbee6f