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Ring -opening of polythiolactones to construct protein-imprinted nanospheres with high recognition and regulation capabilities
- Source :
- Nanoscale. 14(45)
- Publication Year :
- 2022
-
Abstract
- Developing and preparing novel protein-imprinted nanomaterials with high recognition ability remains challenging because it is difficult to controllably and orderly design and arrange functional groups on the imprinted polymer layers of protein-imprinted nanomaterials to improve their protein identification. Herein, we present a new technology using rationally designed polythiolactone-decorated magnetic nanospheres as the precursor of multifunctionalized imprinted materials. Moreover, the strategy of ring-opening the polythiolactione layers using primary amines with terminal alcohols, acids and pyrrolidines introduces abundant recognition sites, which enhance the recognition for template proteins through multiple hydrogen-bonding and hydrophobic interactions. Thiols generated
Details
- ISSN :
- 20403372
- Volume :
- 14
- Issue :
- 45
- Database :
- OpenAIRE
- Journal :
- Nanoscale
- Accession number :
- edsair.doi.dedup.....8f38b29c97f6096edaeb1718f2995e4d