Back to Search
Start Over
Cannabidiol Interactions with Medications, Illicit Substances, and Alcohol: a Comprehensive Review
- Source :
- J Gen Intern Med
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Cannabidiol, a non-intoxicating phytocannabinoid, has potential therapeutic effects over a broad range of disorders. Recently, there has been increased interest in CBD, as several studies showed promising anticonvulsant efficacy with few side effects. In 2018, a CBD-based oral solution, Epidiolex®, was approved by the FDA to treat two severe forms of pediatric epilepsy, Dravet syndrome, and Lennox-Gastaut syndrome. Although only these two syndromes are recognized indications for CBD, it has been consumed in an unregulated fashion for a variety of indications including chronic pain, muscle stiffness, inflammation, anxiety, smoking cessation, and even cancer. While CBD legislation in the USA is confusing due to the differences in state and federal laws, CBD has proliferated in the US market in several forms such as CBD oil or capsules, hemp oil/extract, and also as an ingredient in several dietary supplements, syrups, teas, and creams. With the ever-increasing use of CBD and its widespread availability to the general public, it is important to examine and report on possible drug-drug interactions between CBD and other therapeutic agents as well as addictive substances such as alcohol and tobacco. A detailed literature search for CBD's possible interactions was conducted using online databases. As expected, CBD has been reported to interact with anti-epileptic drugs, antidepressants, opioid analgesics, and THC, but surprisingly, it interacts with several other common medications, e.g. acetaminophen, and substances including alcohol. This review provides a comprehensive list of interacting drugs. The possible mechanisms for these drug-drug interactions are presented in table format. Given the growing popularity of CBD as a medication and the dearth of available information on CBD drug-drug interactions, it is critical to be aware of current drug-drug interactions and it will be important to investigate the impact of CBD upon concomitant medication use in future randomized, controlled trials.
- Subjects :
- medicine.medical_specialty
media_common.quotation_subject
medicine.medical_treatment
Poison control
Epilepsies, Myoclonic
digestive system
01 natural sciences
03 medical and health sciences
0302 clinical medicine
Dravet syndrome
Internal Medicine
medicine
Cannabidiol
Humans
030212 general & internal medicine
0101 mathematics
Child
Intensive care medicine
media_common
Review Paper
Lennox Gastaut Syndrome
Mechanism (biology)
business.industry
Addiction
010102 general mathematics
Chronic pain
medicine.disease
digestive system diseases
surgical procedures, operative
Smoking cessation
Anxiety
Anticonvulsants
medicine.symptom
business
Spasms, Infantile
medicine.drug
Subjects
Details
- ISSN :
- 15251497 and 08848734
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Journal of General Internal Medicine
- Accession number :
- edsair.doi.dedup.....8f334faf476e4c3fe3ef3b56326ec4e4