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Differential time responses in inflammatory and oxidative stress markers after a marathon: An observational study
- Source :
- Journal of Sports Sciences. 38:2080-2091
- Publication Year :
- 2020
- Publisher :
- Informa UK Limited, 2020.
-
Abstract
- Acute and adaptive changes in systemic markers of oxidatively generated nucleic acid modifications (i.e., 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydroguanosine (8-oxoGuo)) as well as inflammatory cytokines (i.e., C-reactive protein, interleukin-6, interleukin-10, and tumour necrosis factor alpha), a liver hormone (i.e., fibroblast growth factor 21 (FGF21)), and bone metabolism markers (sclerostin, osteocalcin, C-terminal telopeptide, and N-terminal propeptide of type 1 procollagen) were investigated following a marathon in 20 study participants. Immediate changes were observed in inflammatory cytokines, FGF21, and bone metabolism markers following the marathon. In contrast, no immediate changes in urinary excretion of 8-oxodG and 8-oxoGuo were evident. Four days after the marathon, decreased urinary excretion of 8-oxodG (-2.9 (95% CI -4.8;-1.1) nmol/24 h,8-oxodG: 8-oxo-7,8-dihydro-2'-deoxyguanosine; 8-oxoGuo: 8-oxo-7,8-dihydroguanosine; CI: confidence interval; CTX: C-terminal telopeptide of type 1 collagen; DXA: dual-energy X-ray absorptiometry; ELISA: enzyme-linked immunosorbent assay; FGF21: Fibroblast growth factor 21; h: hour; hsCRP: high sensitivity C-reactive protein; IL: interleukin; IQR: interquartile range; MS: mass spectrometry: P1NP: N-terminal propeptide of type 1 procollagen; TNFα: tumour necrosis factor alpha; UPLC: ultra-performance liquid chromatography.
- Subjects :
- Male
medicine.medical_specialty
Time Factors
FGF21
030209 endocrinology & metabolism
Physical Therapy, Sports Therapy and Rehabilitation
Adaptive change
Inflammation
medicine.disease_cause
Running
Bone remodeling
Young Adult
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
Orthopedics and Sports Medicine
Chemistry
030229 sport sciences
Oxidative Stress
Endocrinology
8-Hydroxy-2'-Deoxyguanosine
Creatinine
Physical Endurance
Nucleic acid
Cytokines
Bone Remodeling
medicine.symptom
Biomarkers
Oxidative stress
Subjects
Details
- ISSN :
- 1466447X and 02640414
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Journal of Sports Sciences
- Accession number :
- edsair.doi.dedup.....8f20add0c4178813930ccc4253b7a22e