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Phase and power modulations on the amplitude of TMS-induced motor evoked potentials
- Source :
- PLoS One, 16, 9, PLoS One, PLoS One, 16, PLoS ONE, PLOS ONE, 16(9):e0255815. Public Library of Science, PLoS ONE, Vol 16, Iss 9, p e0255815 (2021)
- Publication Year :
- 2021
-
Abstract
- The evaluation of transcranial magnetic stimulation (TMS)-induced motor evoked potentials (MEPs) promises valuable information about fundamental brain related mechanisms and may serve as a diagnostic tool for clinical monitoring of therapeutic progress or surgery procedures. However, reports about spontaneous fluctuations of MEP amplitudes causing high intra-individual variability have led to increased concerns about the reliability of this measure. One possible cause for high variability of MEPs could be neuronal oscillatory activity, which reflects fluctuations of membrane potentials that systematically increase and decrease the excitability of neuronal networks. Here, we investigate the dependence of MEP amplitude on oscillation power and phase by combining the application of single pulse TMS over the primary motor cortex with concurrent recordings of electromyography and electroencephalography. Our results show that MEP amplitude is correlated to alpha phase, alpha power as well as beta phase. These findings may help explain corticospinal excitability fluctuations by highlighting the modulatory effect of alpha and beta phase on MEPs. In the future, controlling for such a causal relationship may allow for the development of new protocols, improve this method as a (diagnostic) tool and increase the specificity and efficacy of general TMS applications.
- Subjects :
- Male
Muscle Physiology
Physiology
medicine.medical_treatment
Social Sciences
270 Language and Computation in Neural Systems
Electromyography
Electroencephalography
Nervous System
Medicine and Health Sciences
Psychology
EEG
PLASTICITY
Evoked Potentials
Clinical Neurophysiology
Physics
Brain Mapping
Multidisciplinary
medicine.diagnostic_test
Motor Evoked Potentials
Motor Cortex
Brain
Transcranial Magnetic Stimulation
Electrophysiology
VARIABILITY
Bioassays and Physiological Analysis
Amplitude
medicine.anatomical_structure
Brain Electrophysiology
EXCITABILITY
SYNCHRONIZATION
Medicine
Female
Sensory Perception
Anatomy
Primary motor cortex
Muscle Electrophysiology
Research Article
Muscle Contraction
Motor cortex
Adult
CORTEX
Imaging Techniques
Science
Neurophysiology
Alpha (ethology)
Neuroimaging
Research and Analysis Methods
Membrane Potential
Young Adult
Motor system
medicine
OSCILLATIONS
Humans
Transcranial Stimulation
Electrophysiological Techniques
Cognitive Psychology
Reproducibility of Results
Biology and Life Sciences
Evoked Potentials, Motor
Motor System
Transcranial magnetic stimulation
BRAIN-STIMULATION
Cognitive Science
Perception
Clinical Medicine
Neuroscience
SYSTEM
RESPONSES
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 16
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- PLOS ONE
- Accession number :
- edsair.doi.dedup.....8f01136e79935fbad605580494ba642d