A Randomized Trial of Off-Site Collaborative Care for Depression in Chronic Hepatitis C Virus

Objective To test the effectiveness of a collaborative depression care model in improving depression and hepatitis C virus (HCV) care. Data Sources/Study Setting Hepatitis C virus clinic patients who screened positive for depression at four Veterans Affairs Hospitals. Study Design We compared off-site depression collaborative care (delivered by depression care manager, pharmacist, and psychiatrist) with usual care in a randomized trial. Primary depression outcomes were treatment response (≥50 percent decrease in 20-item Hopkins Symptoms Checklist [SCL-20] score), remission (mean SCL-20 score